Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXRα by K48/K63-linked polyubiquitination

The resistance mechanisms that limit the efficacy of retinoid therapy in cancer are poorly understood. Sphingosine kinase 2 (SphK2) is a highly conserved enzyme that is mainly located in the nucleus and endoplasmic reticulum. Unlike well-studied sphingosine kinase 1 (SphK1) located in the cytosol, l...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Wen-Na, Cui, Shu-Xiang, Song, Zhi-Yu, Wang, Shu-Qing, Sun, Shi-Yue, Yu, Xin-Feng, Li, Ye, Zhang, Yu-Hang, Gao, Zu-Hua, Qu, Xian-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503636/
https://www.ncbi.nlm.nih.gov/pubmed/28465486
http://dx.doi.org/10.18632/oncotarget.17174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503636/
https://www.ncbi.nlm.nih.gov/pubmed/28465486
http://dx.doi.org/10.18632/oncotarget.17174

Ejemplares similares