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Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXRα by K48/K63-linked polyubiquitination

The resistance mechanisms that limit the efficacy of retinoid therapy in cancer are poorly understood. Sphingosine kinase 2 (SphK2) is a highly conserved enzyme that is mainly located in the nucleus and endoplasmic reticulum. Unlike well-studied sphingosine kinase 1 (SphK1) located in the cytosol, l...

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Detalles Bibliográficos
Autores principales:	Shi, Wen-Na, Cui, Shu-Xiang, Song, Zhi-Yu, Wang, Shu-Qing, Sun, Shi-Yue, Yu, Xin-Feng, Li, Ye, Zhang, Yu-Hang, Gao, Zu-Hua, Qu, Xian-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503636/ https://www.ncbi.nlm.nih.gov/pubmed/28465486 http://dx.doi.org/10.18632/oncotarget.17174

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