The effect of apatinib in the treatment of metastatic renal cell carcinoma: a case report and review of the literature

The aim of this study was to explore the effect of apatinib in the treatment of metastatic renal cell carcinoma (mRCC) and related adverse events. A case of mRCC was reported which recurred after surgery and roferon treatment. The patient was treated with apatinib at a dose of 500 mg orally, twice d...

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Autores principales: Bi, Jinling, Liu, Haiyuan, Huang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503666/
https://www.ncbi.nlm.nih.gov/pubmed/28740436
http://dx.doi.org/10.2147/IMCRJ.S137484
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author Bi, Jinling
Liu, Haiyuan
Huang, Yong
author_facet Bi, Jinling
Liu, Haiyuan
Huang, Yong
author_sort Bi, Jinling
collection PubMed
description The aim of this study was to explore the effect of apatinib in the treatment of metastatic renal cell carcinoma (mRCC) and related adverse events. A case of mRCC was reported which recurred after surgery and roferon treatment. The patient was treated with apatinib at a dose of 500 mg orally, twice daily, 28 days/cycle. The metastatic lesions improved based on computed tomography after apatinib administration in the fourth and eighth month. The progression-free survival of the patient had increased almost to 8 months. The patient showed a good tolerance with only an adverse effect of mild-to-moderate hand-foot syndrome which was managed well. Apatinib is an option for mRCC after previous treatment. However, more and larger trials are still needed.
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spelling pubmed-55036662017-07-24 The effect of apatinib in the treatment of metastatic renal cell carcinoma: a case report and review of the literature Bi, Jinling Liu, Haiyuan Huang, Yong Int Med Case Rep J Case Report The aim of this study was to explore the effect of apatinib in the treatment of metastatic renal cell carcinoma (mRCC) and related adverse events. A case of mRCC was reported which recurred after surgery and roferon treatment. The patient was treated with apatinib at a dose of 500 mg orally, twice daily, 28 days/cycle. The metastatic lesions improved based on computed tomography after apatinib administration in the fourth and eighth month. The progression-free survival of the patient had increased almost to 8 months. The patient showed a good tolerance with only an adverse effect of mild-to-moderate hand-foot syndrome which was managed well. Apatinib is an option for mRCC after previous treatment. However, more and larger trials are still needed. Dove Medical Press 2017-07-04 /pmc/articles/PMC5503666/ /pubmed/28740436 http://dx.doi.org/10.2147/IMCRJ.S137484 Text en © 2017 Bi et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Report
Bi, Jinling
Liu, Haiyuan
Huang, Yong
The effect of apatinib in the treatment of metastatic renal cell carcinoma: a case report and review of the literature
title The effect of apatinib in the treatment of metastatic renal cell carcinoma: a case report and review of the literature
title_full The effect of apatinib in the treatment of metastatic renal cell carcinoma: a case report and review of the literature
title_fullStr The effect of apatinib in the treatment of metastatic renal cell carcinoma: a case report and review of the literature
title_full_unstemmed The effect of apatinib in the treatment of metastatic renal cell carcinoma: a case report and review of the literature
title_short The effect of apatinib in the treatment of metastatic renal cell carcinoma: a case report and review of the literature
title_sort effect of apatinib in the treatment of metastatic renal cell carcinoma: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503666/
https://www.ncbi.nlm.nih.gov/pubmed/28740436
http://dx.doi.org/10.2147/IMCRJ.S137484
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