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Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects
BACKGROUND: Although the exact mechanism of insulin resistance (IR) has not yet been established, IR is the hallmark characteristic of type 2 diabetes mellitus (T2DM). The aim of this study was to examine the relationship between plasma ghrelin levels and IR in Saudi subjects with T2DM. METHODS: Pat...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Endocrine Society
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503868/ https://www.ncbi.nlm.nih.gov/pubmed/28555463 http://dx.doi.org/10.3803/EnM.2017.32.2.230 |
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author | Al Qarni, Ali Ahmed Joatar, Faris Elbahi Das, Nagalla Awad, Mohamed Eltayeb, Mona Al-Zubair, Ahmed Gasim Ali, Muhalab E. Al Masaud, Abdulaziz Shire, Abdirashid M. Gumaa, Khalid Giha, Hayder A. |
author_facet | Al Qarni, Ali Ahmed Joatar, Faris Elbahi Das, Nagalla Awad, Mohamed Eltayeb, Mona Al-Zubair, Ahmed Gasim Ali, Muhalab E. Al Masaud, Abdulaziz Shire, Abdirashid M. Gumaa, Khalid Giha, Hayder A. |
author_sort | Al Qarni, Ali Ahmed |
collection | PubMed |
description | BACKGROUND: Although the exact mechanism of insulin resistance (IR) has not yet been established, IR is the hallmark characteristic of type 2 diabetes mellitus (T2DM). The aim of this study was to examine the relationship between plasma ghrelin levels and IR in Saudi subjects with T2DM. METHODS: Patients with T2DM (n=107, cases) and non-diabetic apparently healthy subjects (n=101, controls) from Saudi Arabia were included in this study. The biochemical profiles and plasma insulin levels of all subjects were analyzed, and IR was estimated using the homeostatic model assessment of insulin resistance (HOMA-IR) index. Active ghrelin levels in plasma were measured using the radioimmunoassay technique. RESULTS: Only 46.7% (50 of 107) of the T2DM subjects had IR, including 26% (28 of 107) with severe IR (HOMA-IR ≥5), while 5.9% (six of 101) of the controls had moderate IR (3 ≤HOMA-IR <5). HOMA-IR values were not associated with age, disease duration, or gender. Importantly, T2DM itself and the co-occurrence of IR with T2DM were significantly associated with low plasma ghrelin levels. However, ghrelin levels were inversely correlated with the HOMA-IR index, body weight, and fasting plasma insulin levels, mainly in the control subjects, which was indicative of the breakdown of metabolic homeostasis in T2DM. CONCLUSION: The prevalence of IR was relatively low, and IR may be inversely associated with plasma ghrelin levels among Saudi patients with T2DM. |
format | Online Article Text |
id | pubmed-5503868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Endocrine Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-55038682017-07-12 Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects Al Qarni, Ali Ahmed Joatar, Faris Elbahi Das, Nagalla Awad, Mohamed Eltayeb, Mona Al-Zubair, Ahmed Gasim Ali, Muhalab E. Al Masaud, Abdulaziz Shire, Abdirashid M. Gumaa, Khalid Giha, Hayder A. Endocrinol Metab (Seoul) Original Article BACKGROUND: Although the exact mechanism of insulin resistance (IR) has not yet been established, IR is the hallmark characteristic of type 2 diabetes mellitus (T2DM). The aim of this study was to examine the relationship between plasma ghrelin levels and IR in Saudi subjects with T2DM. METHODS: Patients with T2DM (n=107, cases) and non-diabetic apparently healthy subjects (n=101, controls) from Saudi Arabia were included in this study. The biochemical profiles and plasma insulin levels of all subjects were analyzed, and IR was estimated using the homeostatic model assessment of insulin resistance (HOMA-IR) index. Active ghrelin levels in plasma were measured using the radioimmunoassay technique. RESULTS: Only 46.7% (50 of 107) of the T2DM subjects had IR, including 26% (28 of 107) with severe IR (HOMA-IR ≥5), while 5.9% (six of 101) of the controls had moderate IR (3 ≤HOMA-IR <5). HOMA-IR values were not associated with age, disease duration, or gender. Importantly, T2DM itself and the co-occurrence of IR with T2DM were significantly associated with low plasma ghrelin levels. However, ghrelin levels were inversely correlated with the HOMA-IR index, body weight, and fasting plasma insulin levels, mainly in the control subjects, which was indicative of the breakdown of metabolic homeostasis in T2DM. CONCLUSION: The prevalence of IR was relatively low, and IR may be inversely associated with plasma ghrelin levels among Saudi patients with T2DM. Korean Endocrine Society 2017-06 2017-05-29 /pmc/articles/PMC5503868/ /pubmed/28555463 http://dx.doi.org/10.3803/EnM.2017.32.2.230 Text en Copyright © 2017 Korean Endocrine Society http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Al Qarni, Ali Ahmed Joatar, Faris Elbahi Das, Nagalla Awad, Mohamed Eltayeb, Mona Al-Zubair, Ahmed Gasim Ali, Muhalab E. Al Masaud, Abdulaziz Shire, Abdirashid M. Gumaa, Khalid Giha, Hayder A. Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects |
title | Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects |
title_full | Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects |
title_fullStr | Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects |
title_full_unstemmed | Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects |
title_short | Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects |
title_sort | association of plasma ghrelin levels with insulin resistance in type 2 diabetes mellitus among saudi subjects |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503868/ https://www.ncbi.nlm.nih.gov/pubmed/28555463 http://dx.doi.org/10.3803/EnM.2017.32.2.230 |
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