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Characterisation of preproendothelin-1 derived peptides identifies Endothelin-Like Domain Peptide as a modulator of Endothelin-1

Endothelin-1 (ET-1) is involved in the pathogenesis of cardiac and renal diseases, and in the progression of tumour growth in cancer, but current diagnosis and treatment remain inadequate. Peptides derived from the 212 amino acid precursor preproendothelin-1 (ppET-1) may have utility as biomarkers,...

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Detalles Bibliográficos
Autores principales:	Yuzugulen, Jale, Douthwaite, Julie A., Wood, Elizabeth G., Villar, Inmaculada C., Patel, Nimesh S. A., Jegard, James, Gaertner, Hubert, Rossitto-Borlat, Irène, Rose, Keith, Hartley, Oliver, Cutillas, Pedro R., Ahluwalia, Amrita, Corder, Roger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503984/ https://www.ncbi.nlm.nih.gov/pubmed/28694457 http://dx.doi.org/10.1038/s41598-017-05365-2

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