5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes

Leukotriene B4 (LTB4) production via the 5-lipoxygenase (5-LO) pathway contributes to the development of insulin resistance in adipose and hepatic tissues, but the role of LTB4 in skeletal muscle is relatively unknown. Here, the authors investigated the role of LTB4 in C2C12 myotubes in palmitic aci...

Descripción completa

Detalles Bibliográficos
Autores principales: Kwak, Hyun Jeong, Choi, Hye-Eun, Cheon, Hyae Gyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504062/
https://www.ncbi.nlm.nih.gov/pubmed/28694473
http://dx.doi.org/10.1038/s41598-017-05346-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504062/
https://www.ncbi.nlm.nih.gov/pubmed/28694473
http://dx.doi.org/10.1038/s41598-017-05346-5

Ejemplares similares