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Gradients of connectivity distance are anchored in primary cortex

Connectivity between distant cortical areas is a valuable, yet costly feature of cortical organization and is predominantly found between regions of heteromodal association cortex. The recently proposed ‘tethering hypothesis’ describes the emergence of long-distance connections in association cortex...

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Autores principales: Oligschläger, Sabine, Huntenburg, Julia M., Golchert, Johannes, Lauckner, Mark E., Bonnen, Tyler, Margulies, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504232/
https://www.ncbi.nlm.nih.gov/pubmed/27807628
http://dx.doi.org/10.1007/s00429-016-1333-7
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author Oligschläger, Sabine
Huntenburg, Julia M.
Golchert, Johannes
Lauckner, Mark E.
Bonnen, Tyler
Margulies, Daniel S.
author_facet Oligschläger, Sabine
Huntenburg, Julia M.
Golchert, Johannes
Lauckner, Mark E.
Bonnen, Tyler
Margulies, Daniel S.
author_sort Oligschläger, Sabine
collection PubMed
description Connectivity between distant cortical areas is a valuable, yet costly feature of cortical organization and is predominantly found between regions of heteromodal association cortex. The recently proposed ‘tethering hypothesis’ describes the emergence of long-distance connections in association cortex as a function of their spatial separation from primary cortical regions. Here, we investigate this possibility by characterizing the distance between functionally connected areas along the cortical surface. We found a systematic relationship between an area’s characteristic connectivity distance and its distance from primary cortical areas. Specifically, the further a region is located from primary sensorimotor regions, the more distant are its functional connections with other areas of the cortex. The measure of connectivity distance also captured major functional subdivisions of the cerebral cortex: unimodal, attention, and higher-order association regions. Our findings provide evidence for the anchoring role of primary cortical regions in establishing the spatial distribution of cortical properties that are related to functional specialization and differentiation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00429-016-1333-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-55042322017-07-25 Gradients of connectivity distance are anchored in primary cortex Oligschläger, Sabine Huntenburg, Julia M. Golchert, Johannes Lauckner, Mark E. Bonnen, Tyler Margulies, Daniel S. Brain Struct Funct Original Article Connectivity between distant cortical areas is a valuable, yet costly feature of cortical organization and is predominantly found between regions of heteromodal association cortex. The recently proposed ‘tethering hypothesis’ describes the emergence of long-distance connections in association cortex as a function of their spatial separation from primary cortical regions. Here, we investigate this possibility by characterizing the distance between functionally connected areas along the cortical surface. We found a systematic relationship between an area’s characteristic connectivity distance and its distance from primary cortical areas. Specifically, the further a region is located from primary sensorimotor regions, the more distant are its functional connections with other areas of the cortex. The measure of connectivity distance also captured major functional subdivisions of the cerebral cortex: unimodal, attention, and higher-order association regions. Our findings provide evidence for the anchoring role of primary cortical regions in establishing the spatial distribution of cortical properties that are related to functional specialization and differentiation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00429-016-1333-7) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2016-11-02 2017 /pmc/articles/PMC5504232/ /pubmed/27807628 http://dx.doi.org/10.1007/s00429-016-1333-7 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Oligschläger, Sabine
Huntenburg, Julia M.
Golchert, Johannes
Lauckner, Mark E.
Bonnen, Tyler
Margulies, Daniel S.
Gradients of connectivity distance are anchored in primary cortex
title Gradients of connectivity distance are anchored in primary cortex
title_full Gradients of connectivity distance are anchored in primary cortex
title_fullStr Gradients of connectivity distance are anchored in primary cortex
title_full_unstemmed Gradients of connectivity distance are anchored in primary cortex
title_short Gradients of connectivity distance are anchored in primary cortex
title_sort gradients of connectivity distance are anchored in primary cortex
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504232/
https://www.ncbi.nlm.nih.gov/pubmed/27807628
http://dx.doi.org/10.1007/s00429-016-1333-7
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