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Gradients of connectivity distance are anchored in primary cortex
Connectivity between distant cortical areas is a valuable, yet costly feature of cortical organization and is predominantly found between regions of heteromodal association cortex. The recently proposed ‘tethering hypothesis’ describes the emergence of long-distance connections in association cortex...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504232/ https://www.ncbi.nlm.nih.gov/pubmed/27807628 http://dx.doi.org/10.1007/s00429-016-1333-7 |
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author | Oligschläger, Sabine Huntenburg, Julia M. Golchert, Johannes Lauckner, Mark E. Bonnen, Tyler Margulies, Daniel S. |
author_facet | Oligschläger, Sabine Huntenburg, Julia M. Golchert, Johannes Lauckner, Mark E. Bonnen, Tyler Margulies, Daniel S. |
author_sort | Oligschläger, Sabine |
collection | PubMed |
description | Connectivity between distant cortical areas is a valuable, yet costly feature of cortical organization and is predominantly found between regions of heteromodal association cortex. The recently proposed ‘tethering hypothesis’ describes the emergence of long-distance connections in association cortex as a function of their spatial separation from primary cortical regions. Here, we investigate this possibility by characterizing the distance between functionally connected areas along the cortical surface. We found a systematic relationship between an area’s characteristic connectivity distance and its distance from primary cortical areas. Specifically, the further a region is located from primary sensorimotor regions, the more distant are its functional connections with other areas of the cortex. The measure of connectivity distance also captured major functional subdivisions of the cerebral cortex: unimodal, attention, and higher-order association regions. Our findings provide evidence for the anchoring role of primary cortical regions in establishing the spatial distribution of cortical properties that are related to functional specialization and differentiation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00429-016-1333-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5504232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-55042322017-07-25 Gradients of connectivity distance are anchored in primary cortex Oligschläger, Sabine Huntenburg, Julia M. Golchert, Johannes Lauckner, Mark E. Bonnen, Tyler Margulies, Daniel S. Brain Struct Funct Original Article Connectivity between distant cortical areas is a valuable, yet costly feature of cortical organization and is predominantly found between regions of heteromodal association cortex. The recently proposed ‘tethering hypothesis’ describes the emergence of long-distance connections in association cortex as a function of their spatial separation from primary cortical regions. Here, we investigate this possibility by characterizing the distance between functionally connected areas along the cortical surface. We found a systematic relationship between an area’s characteristic connectivity distance and its distance from primary cortical areas. Specifically, the further a region is located from primary sensorimotor regions, the more distant are its functional connections with other areas of the cortex. The measure of connectivity distance also captured major functional subdivisions of the cerebral cortex: unimodal, attention, and higher-order association regions. Our findings provide evidence for the anchoring role of primary cortical regions in establishing the spatial distribution of cortical properties that are related to functional specialization and differentiation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00429-016-1333-7) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2016-11-02 2017 /pmc/articles/PMC5504232/ /pubmed/27807628 http://dx.doi.org/10.1007/s00429-016-1333-7 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Oligschläger, Sabine Huntenburg, Julia M. Golchert, Johannes Lauckner, Mark E. Bonnen, Tyler Margulies, Daniel S. Gradients of connectivity distance are anchored in primary cortex |
title | Gradients of connectivity distance are anchored in primary cortex |
title_full | Gradients of connectivity distance are anchored in primary cortex |
title_fullStr | Gradients of connectivity distance are anchored in primary cortex |
title_full_unstemmed | Gradients of connectivity distance are anchored in primary cortex |
title_short | Gradients of connectivity distance are anchored in primary cortex |
title_sort | gradients of connectivity distance are anchored in primary cortex |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504232/ https://www.ncbi.nlm.nih.gov/pubmed/27807628 http://dx.doi.org/10.1007/s00429-016-1333-7 |
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