MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity

A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31(hi)Emcn(hi)), is identified as coupling angiogenesis and osteogenesis. The abundance of type CD31(hi)Emcn(hi) vessels decrease during ageing. Here we show that expression of the miR-497∼195 cluster is high in CD31(hi)Emcn...

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Detalles Bibliográficos
Autores principales: Yang, Mi, Li, Chang-Jun, Sun, Xi, Guo, Qi, Xiao, Ye, Su, Tian, Tu, Man-Li, Peng, Hui, Lu, Qiong, Liu, Qing, He, Hong-Bo, Jiang, Tie-Jian, Lei, Min-Xiang, Wan, Mei, Cao, Xu, Luo, Xiang-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504303/
https://www.ncbi.nlm.nih.gov/pubmed/28685750
http://dx.doi.org/10.1038/ncomms16003

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