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Dual addressing of thymidine synthesis pathways for effective targeting of proliferating melanoma

Here, we examined the potential of blocking the thymidine de novo synthesis pathways for sensitizing melanoma cells to the nucleoside salvage pathway targeting endogenous DNA irradiation. Expression of key nucleotide synthesis and proliferation enzymes thymidylate synthase (TS) and thymidine kinase...

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Detalles Bibliográficos
Autores principales:	Miran, Tara, Vogg, Andreas T. J., El Moussaoui, Laila, Kaiser, Hans‐Jürgen, Drude, Natascha, von Felbert, Verena, Mottaghy, Felix M., Morgenroth, Agnieszka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Clinical Cancer Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504322/ https://www.ncbi.nlm.nih.gov/pubmed/28608446 http://dx.doi.org/10.1002/cam4.1113

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