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Longitudinal study of quality of life in advanced cancer patients on home parenteral nutrition
Since there is little knowledge regarding the quality of life (QoL) of cancer patients on home parenteral nutrition (HPN), we planned a prospective, longitudinal, double‐center study to investigate the changes of QoL in these patients. One hundred and eleven adult cancer patients who were candidates...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504329/ https://www.ncbi.nlm.nih.gov/pubmed/28557362 http://dx.doi.org/10.1002/cam4.1111 |
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author | Cotogni, Paolo De Carli, Luca Passera, Roberto Amerio, Maria Luisa Agnello, Elena Fadda, Maurizio Ossola, Marta Monge, Taira De Francesco, Antonella Bozzetti, Federico |
author_facet | Cotogni, Paolo De Carli, Luca Passera, Roberto Amerio, Maria Luisa Agnello, Elena Fadda, Maurizio Ossola, Marta Monge, Taira De Francesco, Antonella Bozzetti, Federico |
author_sort | Cotogni, Paolo |
collection | PubMed |
description | Since there is little knowledge regarding the quality of life (QoL) of cancer patients on home parenteral nutrition (HPN), we planned a prospective, longitudinal, double‐center study to investigate the changes of QoL in these patients. One hundred and eleven adult cancer patients who were candidates for HPN following the indications of the European guidelines were consecutively enrolled. For QoL analysis, EORTC QLQ‐C30 questionnaires were filled at the HPN start and after 1, 2, 3, and 4 months, and scores changes over time were analyzed according to the univariate mixed‐effects linear model for repeated measures. Most patients had gastrointestinal cancers, were severely malnourished, and were in stage IV; two‐thirds were still receiving oncologic treatments. Median weight loss over 3 months and body mass index were 11.7% and 20.7, respectively. Median survival was 4.7 (1–42) months; 67 and 34% of patients survived 3 and 6 months, respectively. Global QoL, physical functioning, role functioning, emotional functioning, appetite loss, and fatigue scores had a statistically significant trend over time (P < 0.001, P < 0.001, P = 0.007, P < 0.001, P = 0.004, P = 0.022, respectively). At the univariate analyses, the determinants significantly associated with changes in trend over time for physical, role, and emotional functioning were oncologic treatments (P < 0.001, P = 0.014, P = 0.040, respectively) and for appetite loss they were weight loss and Karnofsky performance status (P = 0.003, P = 0.023, respectively). Global QoL, physical, role, and emotional functioning improved during HPN even in advanced cancer patients on oncologic treatments. |
format | Online Article Text |
id | pubmed-5504329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55043292017-07-12 Longitudinal study of quality of life in advanced cancer patients on home parenteral nutrition Cotogni, Paolo De Carli, Luca Passera, Roberto Amerio, Maria Luisa Agnello, Elena Fadda, Maurizio Ossola, Marta Monge, Taira De Francesco, Antonella Bozzetti, Federico Cancer Med Cancer Prevention Since there is little knowledge regarding the quality of life (QoL) of cancer patients on home parenteral nutrition (HPN), we planned a prospective, longitudinal, double‐center study to investigate the changes of QoL in these patients. One hundred and eleven adult cancer patients who were candidates for HPN following the indications of the European guidelines were consecutively enrolled. For QoL analysis, EORTC QLQ‐C30 questionnaires were filled at the HPN start and after 1, 2, 3, and 4 months, and scores changes over time were analyzed according to the univariate mixed‐effects linear model for repeated measures. Most patients had gastrointestinal cancers, were severely malnourished, and were in stage IV; two‐thirds were still receiving oncologic treatments. Median weight loss over 3 months and body mass index were 11.7% and 20.7, respectively. Median survival was 4.7 (1–42) months; 67 and 34% of patients survived 3 and 6 months, respectively. Global QoL, physical functioning, role functioning, emotional functioning, appetite loss, and fatigue scores had a statistically significant trend over time (P < 0.001, P < 0.001, P = 0.007, P < 0.001, P = 0.004, P = 0.022, respectively). At the univariate analyses, the determinants significantly associated with changes in trend over time for physical, role, and emotional functioning were oncologic treatments (P < 0.001, P = 0.014, P = 0.040, respectively) and for appetite loss they were weight loss and Karnofsky performance status (P = 0.003, P = 0.023, respectively). Global QoL, physical, role, and emotional functioning improved during HPN even in advanced cancer patients on oncologic treatments. John Wiley and Sons Inc. 2017-05-29 /pmc/articles/PMC5504329/ /pubmed/28557362 http://dx.doi.org/10.1002/cam4.1111 Text en © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cancer Prevention Cotogni, Paolo De Carli, Luca Passera, Roberto Amerio, Maria Luisa Agnello, Elena Fadda, Maurizio Ossola, Marta Monge, Taira De Francesco, Antonella Bozzetti, Federico Longitudinal study of quality of life in advanced cancer patients on home parenteral nutrition |
title | Longitudinal study of quality of life in advanced cancer patients on home parenteral nutrition |
title_full | Longitudinal study of quality of life in advanced cancer patients on home parenteral nutrition |
title_fullStr | Longitudinal study of quality of life in advanced cancer patients on home parenteral nutrition |
title_full_unstemmed | Longitudinal study of quality of life in advanced cancer patients on home parenteral nutrition |
title_short | Longitudinal study of quality of life in advanced cancer patients on home parenteral nutrition |
title_sort | longitudinal study of quality of life in advanced cancer patients on home parenteral nutrition |
topic | Cancer Prevention |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504329/ https://www.ncbi.nlm.nih.gov/pubmed/28557362 http://dx.doi.org/10.1002/cam4.1111 |
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