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Is hepatic steatosis associated with left ventricular mass index increase in the general population?
AIM: To investigate the association between hepatic steatosis and change in left ventricular mass index (LVMI) over five years, and examine whether systolic and diastolic blood pressures are mediators of the association between hepatic steatosis and LVMI using a general population sample. METHODS: W...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504361/ https://www.ncbi.nlm.nih.gov/pubmed/28740597 http://dx.doi.org/10.4254/wjh.v9.i19.857 |
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author | Piontek, Katharina Schmidt, Carsten O Baumeister, Sebastian E Lerch, Markus M Mayerle, Julia Dörr, Marcus Felix, Stephan B Völzke, Henry |
author_facet | Piontek, Katharina Schmidt, Carsten O Baumeister, Sebastian E Lerch, Markus M Mayerle, Julia Dörr, Marcus Felix, Stephan B Völzke, Henry |
author_sort | Piontek, Katharina |
collection | PubMed |
description | AIM: To investigate the association between hepatic steatosis and change in left ventricular mass index (LVMI) over five years, and examine whether systolic and diastolic blood pressures are mediators of the association between hepatic steatosis and LVMI using a general population sample. METHODS: We analyzed data from the Study of Health in Pomerania. The study population comprised 1298 individuals aged 45 to 81 years. Hepatic steatosis was defined as the presence of a hyperechogenic pattern of the liver together with elevated serum alanine transferase levels. Left ventricular mass was determined echocardiographically and indexed to height(2.7). Path analyses were conducted to differentiate direct and indirect paths from hepatic steatosis to LVMI encompassing systolic and diastolic blood pressure as potential mediating variables. RESULTS: Hepatic steatosis was a significant predictor for all measured echocardiographic characteristics at baseline. Path analyses revealed that the association of hepatic steatosis with LVMI change after five years was negligibly small (β = -0.12, s.e. = 0.21, P = 0.55). Systolic blood pressure at baseline was inversely associated with LVMI change (β = -0.09, s.e. = 0.03, P < 0.01), while no association between diastolic blood pressure at baseline and LVMI change was evident (β = 0.03, s.e. = 0.05, P = 0.56). The effect of the indirect path from hepatic steatosis to LVMI via systolic baseline blood pressure was small (β = -0.20, s.e. = 0.10, P = 0.07). No indirect effect was observed for the path via diastolic baseline blood pressure (β = 0.03, s.e. = 0.06, P = 0.60). Similar associations were observed in the subgroup of individuals not receiving beta-blockers, calcium channel blockers, or drugs acting on the renin-angiotensin system. CONCLUSION: Baseline associations between hepatic steatosis and LVMI do not extend to associations with LVMI change after five years. More studies are needed to study the longitudinal effects of hepatic steatosis on LVMI. |
format | Online Article Text |
id | pubmed-5504361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-55043612017-07-24 Is hepatic steatosis associated with left ventricular mass index increase in the general population? Piontek, Katharina Schmidt, Carsten O Baumeister, Sebastian E Lerch, Markus M Mayerle, Julia Dörr, Marcus Felix, Stephan B Völzke, Henry World J Hepatol Prospective Study AIM: To investigate the association between hepatic steatosis and change in left ventricular mass index (LVMI) over five years, and examine whether systolic and diastolic blood pressures are mediators of the association between hepatic steatosis and LVMI using a general population sample. METHODS: We analyzed data from the Study of Health in Pomerania. The study population comprised 1298 individuals aged 45 to 81 years. Hepatic steatosis was defined as the presence of a hyperechogenic pattern of the liver together with elevated serum alanine transferase levels. Left ventricular mass was determined echocardiographically and indexed to height(2.7). Path analyses were conducted to differentiate direct and indirect paths from hepatic steatosis to LVMI encompassing systolic and diastolic blood pressure as potential mediating variables. RESULTS: Hepatic steatosis was a significant predictor for all measured echocardiographic characteristics at baseline. Path analyses revealed that the association of hepatic steatosis with LVMI change after five years was negligibly small (β = -0.12, s.e. = 0.21, P = 0.55). Systolic blood pressure at baseline was inversely associated with LVMI change (β = -0.09, s.e. = 0.03, P < 0.01), while no association between diastolic blood pressure at baseline and LVMI change was evident (β = 0.03, s.e. = 0.05, P = 0.56). The effect of the indirect path from hepatic steatosis to LVMI via systolic baseline blood pressure was small (β = -0.20, s.e. = 0.10, P = 0.07). No indirect effect was observed for the path via diastolic baseline blood pressure (β = 0.03, s.e. = 0.06, P = 0.60). Similar associations were observed in the subgroup of individuals not receiving beta-blockers, calcium channel blockers, or drugs acting on the renin-angiotensin system. CONCLUSION: Baseline associations between hepatic steatosis and LVMI do not extend to associations with LVMI change after five years. More studies are needed to study the longitudinal effects of hepatic steatosis on LVMI. Baishideng Publishing Group Inc 2017-07-08 2017-07-08 /pmc/articles/PMC5504361/ /pubmed/28740597 http://dx.doi.org/10.4254/wjh.v9.i19.857 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Prospective Study Piontek, Katharina Schmidt, Carsten O Baumeister, Sebastian E Lerch, Markus M Mayerle, Julia Dörr, Marcus Felix, Stephan B Völzke, Henry Is hepatic steatosis associated with left ventricular mass index increase in the general population? |
title | Is hepatic steatosis associated with left ventricular mass index increase in the general population? |
title_full | Is hepatic steatosis associated with left ventricular mass index increase in the general population? |
title_fullStr | Is hepatic steatosis associated with left ventricular mass index increase in the general population? |
title_full_unstemmed | Is hepatic steatosis associated with left ventricular mass index increase in the general population? |
title_short | Is hepatic steatosis associated with left ventricular mass index increase in the general population? |
title_sort | is hepatic steatosis associated with left ventricular mass index increase in the general population? |
topic | Prospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504361/ https://www.ncbi.nlm.nih.gov/pubmed/28740597 http://dx.doi.org/10.4254/wjh.v9.i19.857 |
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