Expression and role of nuclear receptor coregulators in colorectal cancer

Colorectal cancer (CRC) is one of the most common human cancers and the cause of about 700000 deaths per year worldwide. Deregulation of the WNT/β-catenin pathway is a key event in CRC initiation. This pathway interacts with other nuclear signaling pathways, including members of the nuclear receptor...

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Autores principales: Triki, Mouna, Lapierre, Marion, Cavailles, Vincent, Mokdad-Gargouri, Raja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504363/
https://www.ncbi.nlm.nih.gov/pubmed/28740336
http://dx.doi.org/10.3748/wjg.v23.i25.4480
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author Triki, Mouna
Lapierre, Marion
Cavailles, Vincent
Mokdad-Gargouri, Raja
author_facet Triki, Mouna
Lapierre, Marion
Cavailles, Vincent
Mokdad-Gargouri, Raja
author_sort Triki, Mouna
collection PubMed
description Colorectal cancer (CRC) is one of the most common human cancers and the cause of about 700000 deaths per year worldwide. Deregulation of the WNT/β-catenin pathway is a key event in CRC initiation. This pathway interacts with other nuclear signaling pathways, including members of the nuclear receptor superfamily and their transcription coregulators. In this review, we provide an overview of the literature dealing with the main coactivators (NCoA-1 to 3, NCoA-6, PGC1-α, p300, CREBBP and MED1) and corepressors (N-CoR1 and 2, NRIP1 and MTA1) of nuclear receptors and summarize their links with the WNT/β-catenin signaling cascade, their expression in CRC and their role in intestinal physiopathology.
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spelling pubmed-55043632017-07-24 Expression and role of nuclear receptor coregulators in colorectal cancer Triki, Mouna Lapierre, Marion Cavailles, Vincent Mokdad-Gargouri, Raja World J Gastroenterol Review Colorectal cancer (CRC) is one of the most common human cancers and the cause of about 700000 deaths per year worldwide. Deregulation of the WNT/β-catenin pathway is a key event in CRC initiation. This pathway interacts with other nuclear signaling pathways, including members of the nuclear receptor superfamily and their transcription coregulators. In this review, we provide an overview of the literature dealing with the main coactivators (NCoA-1 to 3, NCoA-6, PGC1-α, p300, CREBBP and MED1) and corepressors (N-CoR1 and 2, NRIP1 and MTA1) of nuclear receptors and summarize their links with the WNT/β-catenin signaling cascade, their expression in CRC and their role in intestinal physiopathology. Baishideng Publishing Group Inc 2017-07-07 2017-07-07 /pmc/articles/PMC5504363/ /pubmed/28740336 http://dx.doi.org/10.3748/wjg.v23.i25.4480 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Triki, Mouna
Lapierre, Marion
Cavailles, Vincent
Mokdad-Gargouri, Raja
Expression and role of nuclear receptor coregulators in colorectal cancer
title Expression and role of nuclear receptor coregulators in colorectal cancer
title_full Expression and role of nuclear receptor coregulators in colorectal cancer
title_fullStr Expression and role of nuclear receptor coregulators in colorectal cancer
title_full_unstemmed Expression and role of nuclear receptor coregulators in colorectal cancer
title_short Expression and role of nuclear receptor coregulators in colorectal cancer
title_sort expression and role of nuclear receptor coregulators in colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504363/
https://www.ncbi.nlm.nih.gov/pubmed/28740336
http://dx.doi.org/10.3748/wjg.v23.i25.4480
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