Cargando…

Exploring the relationship between α-actinin-3 deficiency and obesity in mice and humans

Obesity is a worldwide health crisis, and the identification of genetic modifiers of weight gain is crucial in understanding this complex disorder. A common null polymorphism in the fast fiber-specific gene ACTN3 (R577X) is known to influence skeletal muscle function and metabolism. α-Actinin-3 defi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Houweling, P J, Berman, Y D, Turner, N, Quinlan, K G R, Seto, J T, Yang, N, Lek, M, Macarthur, D G, Cooney, G, North, K N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504447/ https://www.ncbi.nlm.nih.gov/pubmed/28293018 http://dx.doi.org/10.1038/ijo.2017.72

Ejemplares similares

Altered Ca(2+) Kinetics Associated with α-Actinin-3 Deficiency May Explain Positive Selection for ACTN3 Null Allele in Human Evolution
por: Head, Stewart I., et al.
Publicado: (2015)

Loss of α-actinin-3 confers protection from eccentric contraction damage in fast-twitch EDL muscles from aged mdx dystrophic mice by reducing pathological fibre branching
por: Kiriaev, Leonit, et al.
Publicado: (2021)

A “human knockout” model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations
por: Papadimitriou, I. D., et al.
Publicado: (2019)

Loss of α-actinin-3 during human evolution provides superior cold resilience and muscle heat generation
por: Wyckelsma, Victoria L., et al.
Publicado: (2021)

Absence of the Z-disc protein α-actinin-3 impairs the mechanical stability of Actn3KO mouse fast-twitch muscle fibres without altering their contractile properties or twitch kinetics
por: Haug, Michael, et al.
Publicado: (2022)

UDP-N-Acetylglucosamine 2-Epimerase/N-Acetylmannosamine Kinase (GNE) Binds to Alpha-Actinin 1: Novel Pathways in Skeletal Muscle?
por: Amsili, Shira, et al.
Publicado: (2008)

Characterisation of Schizosaccharomyces pombe α-actinin
por: Addario, Barbara, et al.
Publicado: (2016)

Preliminary Findings of α -Actinin-3 Gene Distribution in Elite Turkish Wind Surfers
por: Ulucan, K, et al.
Publicado: ( 201)

Characterization of the interaction between Actinin-Associated LIM Protein (ALP) and the rod domain of α-actinin
por: Klaavuniemi, Tuula, et al.
Publicado: (2009)

Podocyte Injury Associated with Mutant α-Actinin-4
por: Cybulsky, Andrey V., et al.
Publicado: (2011)

Calcium affinity of human α-actinin 1
por: Backman, Lars
Publicado: (2015)

The Structure and Regulation of Human Muscle α-Actinin
por: Ribeiro, Euripedes de Almeida, et al.
Publicado: (2014)

The domain structure of Entamoeba α-actinin2
por: Addario, Barbara, et al.
Publicado: (2010)

The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3
por: Agarwal, Sunita K, et al.
Publicado: (2008)

Limited digestion of α-actinin in the presence of F-actin
por: Jia, You, et al.
Publicado: (2011)

Exploring genetic markers of adult obesity risk in black adolescent South Africans—the Birth to Twenty Cohort
por: Pillay, V, et al.
Publicado: (2015)

The Alström Syndrome Protein, ALMS1, Interacts with α-Actinin and Components of the Endosome Recycling Pathway
por: Collin, Gayle B., et al.
Publicado: (2012)

Neisseria meningitidis Opc invasin binds to the cytoskeletal protein α-actinin
por: Sa E Cunha, Claudia, et al.
Publicado: (2009)

Molecular Mechanics of the α-Actinin Rod Domain: Bending, Torsional, and Extensional Behavior
por: Golji, Javad, et al.
Publicado: (2009)

Distribution of flourescently labeled α-actinin in living and fixed fibroblasts
por: Feramisco,, et al.
Publicado: (1980)

HAMLET Binding to α-Actinin Facilitates Tumor Cell Detachment
por: Trulsson, Maria, et al.
Publicado: (2011)

Isoform-Specific Contributions of α-Actinin to Glioma Cell Mechanobiology
por: Sen, Shamik, et al.
Publicado: (2009)

α-Actinin-3: Why Gene Loss Is an Evolutionary Gain
por: Ivarsson, Niklas, et al.
Publicado: (2015)

ICAM-5 affects spine maturation by regulation of NMDA receptor binding to α-actinin
por: Ning, Lin, et al.
Publicado: (2015)

Molecular basis of interactions between CaMKII and α-actinin-2 that underlie dendritic spine enlargement
por: Curtis, Ashton J, et al.
Publicado: (2023)

Dynamic Alterations to α-Actinin Accompanying Sarcomere Disassembly and Reassembly during Cardiomyocyte Mitosis
por: Fan, Xiaohu, et al.
Publicado: (2015)

α-Actinin and Filamin Cooperatively Enhance the Stiffness of Actin Filament Networks
por: Esue, Osigwe, et al.
Publicado: (2009)

α-Actinin-4 Is Essential for Maintaining the Spreading, Motility and Contractility of Fibroblasts
por: Shao, Hanshuang, et al.
Publicado: (2010)

The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis
por: Youinou, Pierre, et al.
Publicado: (2009)

Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast
por: Christensen, Jenna R, et al.
Publicado: (2019)

Interaction of annexin A6 with alpha actinin in cardiomyocytes
por: Mishra, Sumita, et al.
Publicado: (2011)

Cardiac MLC2 kinase is localized to the Z-disc and interacts with α-actinin2
por: X. Cai, Lawrence, et al.
Publicado: (2019)

Assembly Kinetics Determine the Architecture of α-actinin Crosslinked F-actin Networks
por: Falzone, Tobias T., et al.
Publicado: (2012)

Polymorphism of the ace gene and the α-actinin-3 gene in adolescent idiopathic scoliosis
por: Wajchenberg, Marcelo, et al.
Publicado: (2013)

Synaptopodin couples epithelial contractility to α-actinin-4–dependent junction maturation
por: Kannan, Nivetha, et al.
Publicado: (2015)

Dynamin 2 interacts with α-actinin 4 to drive tumor cell invasion
por: Burton, Kevin M., et al.
Publicado: (2020)

Differential Dynamics of α5 Integrin, Paxillin, and α-Actinin during Formation and Disassembly of Adhesions in Migrating Cells
por: Laukaitis, Christina M., et al.
Publicado: (2001)

Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy
por: Prondzynski, Maksymilian, et al.
Publicado: (2019)

Socio-economic status influences the relationship between obesity and antenatal depression: Data from a prospective cohort study
por: Molyneaux, E., et al.
Publicado: (2016)

The Cytoskeletal Protein α-Actinin Regulates Acid-sensing Ion Channel 1a through a C-terminal Interaction
por: Schnizler, Mikael K., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_jrqkfahl8cvd7qhge16qsqnobr