Metabolic Profile of Obeticholic Acid and Endogenous Bile Acids in Rats with Decompensated Liver Cirrhosis

Obeticholic acid (OCA) is a semisynthetic bile acid (BA) analog and potent farnesoid X receptor agonist approved to treat cholestasis. We evaluated the biodistribution and metabolism of OCA administered to carbon tetrachloride‐induced cirrhotic rats. This was to ascertain if plasma and hepatic conce...

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Detalles Bibliográficos
Autores principales: Roda, A, Aldini, R, Camborata, C, Spinozzi, S, Franco, P, Cont, M, D'Errico, A, Vasuri, F, Degiovanni, A, Maroni, L, Adorini, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504479/
https://www.ncbi.nlm.nih.gov/pubmed/28411380
http://dx.doi.org/10.1111/cts.12468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504479/
https://www.ncbi.nlm.nih.gov/pubmed/28411380
http://dx.doi.org/10.1111/cts.12468

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