Influence of OATP1B1 Function on the Disposition of Sorafenib‐β‐D‐Glucuronide

The oral multikinase inhibitor sorafenib undergoes extensive UGT1A9‐mediated formation of sorafenib‐β‐D‐glucuronide (SG). Using transporter‐deficient mouse models, it was previously established that SG can be extruded into bile by ABCC2 or follow a liver‐to‐blood shuttling loop via ABCC3‐mediated ef...

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Detalles Bibliográficos
Autores principales: Bins, S, van Doorn, L, Phelps, MA, Gibson, AA, Hu, S, Li, L, Vasilyeva, A, Du, G, Hamberg, P, Eskens, FALM, de Bruijn, P, Sparreboom, A, Mathijssen, RHJ, Baker, SD
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504481/
https://www.ncbi.nlm.nih.gov/pubmed/28371445
http://dx.doi.org/10.1111/cts.12458

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