Oxidation of Secondary Methyl Ethers to Ketones

[Image: see text] We present a mild way of converting secondary methyl ethers into ketones using calcium hypochlorite in aqueous acetonitrile with acetic acid as activator. The reaction is compatible with various oxygen- and nitrogen-containing functional groups and afforded the corresponding ketone...

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Detalles Bibliográficos
Autores principales: Gilissen, Pieter J., Blanco-Ania, Daniel, Rutjes, Floris P. J. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504491/
https://www.ncbi.nlm.nih.gov/pubmed/28585818
http://dx.doi.org/10.1021/acs.joc.7b00632
Descripción
Sumario:[Image: see text] We present a mild way of converting secondary methyl ethers into ketones using calcium hypochlorite in aqueous acetonitrile with acetic acid as activator. The reaction is compatible with various oxygen- and nitrogen-containing functional groups and afforded the corresponding ketones in up to 98% yield. The use of this methodology could expand the application of the methyl group as a useful protecting group.

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