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Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies

BACKGROUND: Anorexia nervosa is characterized by a severe restriction of caloric intake, low body weight, fear of gaining weight or of becoming fat, and disturbance of body image. Pathogenesis of the disorder may include genetic predisposition, hormonal changes and a combination of environmental, ps...

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Autores principales: Catalá-López, Ferrán, Hutton, Brian, Driver, Jane A., Ridao, Manuel, Valderas, José M., Gènova-Maleras, Ricard, Forés-Martos, Jaume, Alonso-Arroyo, Adolfo, Saint-Gerons, Diego Macías, Vieta, Eduard, Valencia, Alfonso, Tabarés-Seisdedos, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504548/
https://www.ncbi.nlm.nih.gov/pubmed/28693568
http://dx.doi.org/10.1186/s13643-017-0540-5
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author Catalá-López, Ferrán
Hutton, Brian
Driver, Jane A.
Ridao, Manuel
Valderas, José M.
Gènova-Maleras, Ricard
Forés-Martos, Jaume
Alonso-Arroyo, Adolfo
Saint-Gerons, Diego Macías
Vieta, Eduard
Valencia, Alfonso
Tabarés-Seisdedos, Rafael
author_facet Catalá-López, Ferrán
Hutton, Brian
Driver, Jane A.
Ridao, Manuel
Valderas, José M.
Gènova-Maleras, Ricard
Forés-Martos, Jaume
Alonso-Arroyo, Adolfo
Saint-Gerons, Diego Macías
Vieta, Eduard
Valencia, Alfonso
Tabarés-Seisdedos, Rafael
author_sort Catalá-López, Ferrán
collection PubMed
description BACKGROUND: Anorexia nervosa is characterized by a severe restriction of caloric intake, low body weight, fear of gaining weight or of becoming fat, and disturbance of body image. Pathogenesis of the disorder may include genetic predisposition, hormonal changes and a combination of environmental, psychosocial, and cultural factors. Cancer is the second leading cause of death worldwide. At present, no systematic reviews and meta-analyses have evaluated the risk of cancer in people with anorexia nervosa. The objective of this study will be to evaluate the association between anorexia nervosa and the risk of developing or dying from cancer. METHODS/DESIGN: This study protocol is part of a systematic collection and assessment of multiple systematic reviews and meta-analyses (umbrella review) evaluating the association of cancer and multiple central nervous system disorders. We designed a specific protocol for a new systematic review and meta-analysis of observational studies of anorexia nervosa with risk of developing or dying from any cancer. Data sources will be PubMed, Embase, Scopus, Web of Science, and manual screening of references. Observational studies (case–control and cohort) in humans that examined the association between anorexia nervosa and risk of developing or dying from cancer will be sought. The primary outcomes will be cancer incidence and cancer mortality in association with anorexia nervosa. Secondary outcomes will be site-specific cancer incidence and mortality, respectively. Screening of abstracts and full texts, and data abstraction will be performed by two team members independently. Conflicts at all levels of screening and abstraction will be resolved through discussion. The quality of studies will be assessed by using the Ottawa-Newcastle scale by two team members independently. Random effects models will be conducted where appropriate. Subgroup and additional analyses will be conducted to explore the potential sources of heterogeneity. The World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) criteria and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be used for determining the quality of evidence for cancer outcomes. DISCUSSION: Findings from this systematic review will inform an ongoing umbrella review on cancer and central nervous system disorders. Our systematic review and meta-analysis of observational studies will establish the extent of the epidemiological evidence underlying the association between anorexia nervosa and cancer. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42017067462. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13643-017-0540-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-55045482017-07-12 Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies Catalá-López, Ferrán Hutton, Brian Driver, Jane A. Ridao, Manuel Valderas, José M. Gènova-Maleras, Ricard Forés-Martos, Jaume Alonso-Arroyo, Adolfo Saint-Gerons, Diego Macías Vieta, Eduard Valencia, Alfonso Tabarés-Seisdedos, Rafael Syst Rev Protocol BACKGROUND: Anorexia nervosa is characterized by a severe restriction of caloric intake, low body weight, fear of gaining weight or of becoming fat, and disturbance of body image. Pathogenesis of the disorder may include genetic predisposition, hormonal changes and a combination of environmental, psychosocial, and cultural factors. Cancer is the second leading cause of death worldwide. At present, no systematic reviews and meta-analyses have evaluated the risk of cancer in people with anorexia nervosa. The objective of this study will be to evaluate the association between anorexia nervosa and the risk of developing or dying from cancer. METHODS/DESIGN: This study protocol is part of a systematic collection and assessment of multiple systematic reviews and meta-analyses (umbrella review) evaluating the association of cancer and multiple central nervous system disorders. We designed a specific protocol for a new systematic review and meta-analysis of observational studies of anorexia nervosa with risk of developing or dying from any cancer. Data sources will be PubMed, Embase, Scopus, Web of Science, and manual screening of references. Observational studies (case–control and cohort) in humans that examined the association between anorexia nervosa and risk of developing or dying from cancer will be sought. The primary outcomes will be cancer incidence and cancer mortality in association with anorexia nervosa. Secondary outcomes will be site-specific cancer incidence and mortality, respectively. Screening of abstracts and full texts, and data abstraction will be performed by two team members independently. Conflicts at all levels of screening and abstraction will be resolved through discussion. The quality of studies will be assessed by using the Ottawa-Newcastle scale by two team members independently. Random effects models will be conducted where appropriate. Subgroup and additional analyses will be conducted to explore the potential sources of heterogeneity. The World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) criteria and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be used for determining the quality of evidence for cancer outcomes. DISCUSSION: Findings from this systematic review will inform an ongoing umbrella review on cancer and central nervous system disorders. Our systematic review and meta-analysis of observational studies will establish the extent of the epidemiological evidence underlying the association between anorexia nervosa and cancer. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42017067462. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13643-017-0540-5) contains supplementary material, which is available to authorized users. BioMed Central 2017-07-11 /pmc/articles/PMC5504548/ /pubmed/28693568 http://dx.doi.org/10.1186/s13643-017-0540-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Protocol
Catalá-López, Ferrán
Hutton, Brian
Driver, Jane A.
Ridao, Manuel
Valderas, José M.
Gènova-Maleras, Ricard
Forés-Martos, Jaume
Alonso-Arroyo, Adolfo
Saint-Gerons, Diego Macías
Vieta, Eduard
Valencia, Alfonso
Tabarés-Seisdedos, Rafael
Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies
title Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies
title_full Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies
title_fullStr Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies
title_full_unstemmed Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies
title_short Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies
title_sort anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504548/
https://www.ncbi.nlm.nih.gov/pubmed/28693568
http://dx.doi.org/10.1186/s13643-017-0540-5
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