The distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse model

BACKGROUND: Additional sex combs-like 1 (ASXL1) is frequently mutated in myeloid malignancies. Recent studies showed that hematopoietic-specific deletion of Asxl1 or overexpression of mutant ASXL1 resulted in myelodysplasia-like disease in mice. However, actual effects of a “physiological” dose of m...

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Detalles Bibliográficos
Autores principales: Hsu, Yueh-Chwen, Chiu, Yu-Chiao, Lin, Chien-Chin, Kuo, Yuan-Yeh, Hou, Hsin-An, Tzeng, Yi-Shiuan, Kao, Chein-Jun, Chuang, Po-Han, Tseng, Mei-Hsuan, Hsiao, Tzu-Hung, Chou, Wen-Chien, Tien, Hwei-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504705/
https://www.ncbi.nlm.nih.gov/pubmed/28697759
http://dx.doi.org/10.1186/s13045-017-0508-x

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