Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure

BACKGROUND: In homeotherms, the alpha-globin gene clusters are located within permanently open genome regions enriched in housekeeping genes. Terminal erythroid differentiation results in dramatic upregulation of alpha-globin genes making their expression comparable to the rRNA transcriptional outpu...

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Detalles Bibliográficos
Autores principales: Ulianov, Sergey V., Galitsyna, Aleksandra A., Flyamer, Ilya M., Golov, Arkadiy K., Khrameeva, Ekaterina E., Imakaev, Maxim V., Abdennur, Nezar A., Gelfand, Mikhail S., Gavrilov, Alexey A., Razin, Sergey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504709/
https://www.ncbi.nlm.nih.gov/pubmed/28693562
http://dx.doi.org/10.1186/s13072-017-0142-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504709/
https://www.ncbi.nlm.nih.gov/pubmed/28693562
http://dx.doi.org/10.1186/s13072-017-0142-4

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