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Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure
BACKGROUND: In homeotherms, the alpha-globin gene clusters are located within permanently open genome regions enriched in housekeeping genes. Terminal erythroid differentiation results in dramatic upregulation of alpha-globin genes making their expression comparable to the rRNA transcriptional outpu...
Autores principales: | Ulianov, Sergey V., Galitsyna, Aleksandra A., Flyamer, Ilya M., Golov, Arkadiy K., Khrameeva, Ekaterina E., Imakaev, Maxim V., Abdennur, Nezar A., Gelfand, Mikhail S., Gavrilov, Alexey A., Razin, Sergey V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504709/ https://www.ncbi.nlm.nih.gov/pubmed/28693562 http://dx.doi.org/10.1186/s13072-017-0142-4 |
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