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Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis
Quercetin is a flavonoid widely studied as a chemopreventive agent in different types of cancer. Previously, we reported that quercetin has a chemopreventive effect on the liver-induced preneoplastic lesions in rats. Here, we evaluated if quercetin was able not only to prevent but also to reverse ra...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504959/ https://www.ncbi.nlm.nih.gov/pubmed/28740570 http://dx.doi.org/10.1155/2017/4674918 |
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author | Carrasco-Torres, Gabriela Monroy-Ramírez, Hugo Christian Martínez-Guerra, Arturo Axayacatl Baltiérrez-Hoyos, Rafael Romero-Tlalolini, María de los Ángeles Villa-Treviño, Saúl Sánchez-Chino, Xariss Vásquez-Garzón, Verónica Rocío |
author_facet | Carrasco-Torres, Gabriela Monroy-Ramírez, Hugo Christian Martínez-Guerra, Arturo Axayacatl Baltiérrez-Hoyos, Rafael Romero-Tlalolini, María de los Ángeles Villa-Treviño, Saúl Sánchez-Chino, Xariss Vásquez-Garzón, Verónica Rocío |
author_sort | Carrasco-Torres, Gabriela |
collection | PubMed |
description | Quercetin is a flavonoid widely studied as a chemopreventive agent in different types of cancer. Previously, we reported that quercetin has a chemopreventive effect on the liver-induced preneoplastic lesions in rats. Here, we evaluated if quercetin was able not only to prevent but also to reverse rat liver preneoplastic lesions. We used the modified resistant hepatocyte model (MRHM) to evaluate this possibility. Treatment with quercetin was used 15 days after the induction of preneoplastic lesions. We found that quercetin reverses the number of preneoplastic lesions and their areas. Our results showed that quercetin downregulates the expression of EGFR and modulates this signaling pathway in spite of the activated status of EGFR as detected by the upregulation of this receptor, with respect to that observed in control rats. Besides, quercetin affects the phosphorylation status of Src-1, STAT5, and Sp-1. The better status of the liver after the treatment with quercetin could also be confirmed by the recovery in the expression of IGF-1. In conclusion, we suggest that quercetin reversed preneoplastic lesions by EGFR modulation and the activation state of Src, STAT5, and Sp1, so as the basal IGF-1. |
format | Online Article Text |
id | pubmed-5504959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-55049592017-07-24 Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis Carrasco-Torres, Gabriela Monroy-Ramírez, Hugo Christian Martínez-Guerra, Arturo Axayacatl Baltiérrez-Hoyos, Rafael Romero-Tlalolini, María de los Ángeles Villa-Treviño, Saúl Sánchez-Chino, Xariss Vásquez-Garzón, Verónica Rocío Oxid Med Cell Longev Research Article Quercetin is a flavonoid widely studied as a chemopreventive agent in different types of cancer. Previously, we reported that quercetin has a chemopreventive effect on the liver-induced preneoplastic lesions in rats. Here, we evaluated if quercetin was able not only to prevent but also to reverse rat liver preneoplastic lesions. We used the modified resistant hepatocyte model (MRHM) to evaluate this possibility. Treatment with quercetin was used 15 days after the induction of preneoplastic lesions. We found that quercetin reverses the number of preneoplastic lesions and their areas. Our results showed that quercetin downregulates the expression of EGFR and modulates this signaling pathway in spite of the activated status of EGFR as detected by the upregulation of this receptor, with respect to that observed in control rats. Besides, quercetin affects the phosphorylation status of Src-1, STAT5, and Sp-1. The better status of the liver after the treatment with quercetin could also be confirmed by the recovery in the expression of IGF-1. In conclusion, we suggest that quercetin reversed preneoplastic lesions by EGFR modulation and the activation state of Src, STAT5, and Sp1, so as the basal IGF-1. Hindawi 2017 2017-06-27 /pmc/articles/PMC5504959/ /pubmed/28740570 http://dx.doi.org/10.1155/2017/4674918 Text en Copyright © 2017 Gabriela Carrasco-Torres et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Carrasco-Torres, Gabriela Monroy-Ramírez, Hugo Christian Martínez-Guerra, Arturo Axayacatl Baltiérrez-Hoyos, Rafael Romero-Tlalolini, María de los Ángeles Villa-Treviño, Saúl Sánchez-Chino, Xariss Vásquez-Garzón, Verónica Rocío Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis |
title | Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis |
title_full | Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis |
title_fullStr | Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis |
title_full_unstemmed | Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis |
title_short | Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis |
title_sort | quercetin reverses rat liver preneoplastic lesions induced by chemical carcinogenesis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504959/ https://www.ncbi.nlm.nih.gov/pubmed/28740570 http://dx.doi.org/10.1155/2017/4674918 |
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