Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery

Extracellular vesicles (EVs) hold great potential as novel systems for nucleic acid delivery due to their natural composition. Our goal was to load EVs with microRNA that are synthesized by the cells that produce the EVs. HEK293T cells were engineered to produce EVs expressing a lysosomal associated...

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Detalles Bibliográficos
Autores principales: Sutaria, Dhruvitkumar S., Jiang, Jinmai, Elgamal, Ola A., Pomeroy, Steven M., Badawi, Mohamed, Zhu, Xiaohua, Pavlovicz, Ryan, Azevedo-Pouly, Ana Clara P., Chalmers, Jeffrey, Li, Chenglong, Phelps, Mitch A., Schmittgen, Thomas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505005/
https://www.ncbi.nlm.nih.gov/pubmed/28717424
http://dx.doi.org/10.1080/20013078.2017.1333882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505005/
https://www.ncbi.nlm.nih.gov/pubmed/28717424
http://dx.doi.org/10.1080/20013078.2017.1333882

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