Boosting the Peroxidase-Like Activity of Nanostructured Nickel by Inducing Its 3+ Oxidation State in LaNiO(3) Perovskite and Its Application for Biomedical Assays

Catalytic nanomaterials with intrinsic enzyme-like activities, called nanozymes, have recently attracted significant research interest due to their unique advantages relative to natural enzymes and conventional artificial enzymes. Among the nanozymes developed, particular interests have been devoted to nanozymes with peroxidase mimicking activities because of their promising applications in biosensing, bioimaging, biomedicine, etc. Till now, lots of functional nanomaterials have been used to mimic peroxidase. However, few studies have focused on the Ni-based nanomaterials for peroxidase mimics. In this work, we obtained the porous LaNiO(3) nanocubes with high peroxidase-like activity by inducing its 3+ oxidation state in LaNiO(3) perovskite and optimizing the morphology of LaNiO(3) perovskite. The peroxidase mimicking activity of the porous LaNiO(3) nanocubes with Ni(3+) was about 58~fold and 22~fold higher than that of NiO with Ni(2+) and Ni nanoparticles with Ni(0). More, the porous LaNiO(3) nanocubes exhibited about 2-fold higher activity when compared with LaNiO(3) nanoparticles. Based on the superior peroxidase-like activity of porous LaNiO(3) nanocubes, facile colorimetric assays for H(2)O(2), glucose, and sarcosine detection were developed. Our present work not only demonstrates a useful strategy for modulating nanozymes' activities but also provides promising bioassays for clinical diagnostics.