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Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

PURPOSE: Treatment of inherited retinal degenerations using adeno-associated viral (AAV) vectors involves delivery by subretinal injection. In the latter stages, alteration of normal anatomy may cause difficulty in visualizing the retinotomy, retinal detachment extension, and vector diffusion. Vital...

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Detalles Bibliográficos
Autores principales:	Salvetti, Anna P., Patrício, Maria I., Barnard, Alun R., Orlans, Harry O., Hickey, Doron G., MacLaren, Robert E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505121/ https://www.ncbi.nlm.nih.gov/pubmed/28706756 http://dx.doi.org/10.1167/tvst.6.4.4

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