Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

Current T cell engineering approaches redirect patient T cells to tumors by transducing antigen–specific T cell receptors (TCRs) or chimeric antigen receptors (CARs) that target a single antigen.(1–3) However, few tumor-specific antigens have been identified, and healthy tissues that express the tar...

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Detalles Bibliográficos
Autores principales: Kloss, Christopher C, Condomines, Maud, Cartellieri, Marc, Bachmann, Michael, Sadelain, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505184/
https://www.ncbi.nlm.nih.gov/pubmed/23242161
http://dx.doi.org/10.1038/nbt.2459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505184/
https://www.ncbi.nlm.nih.gov/pubmed/23242161
http://dx.doi.org/10.1038/nbt.2459

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