Cargando…
Effect of Switching From an Anti-Diabetic Loose Dose Combination to a Fixed Dose Combination Regimen at Equivalent Dosage for 6 Months on Glycemic Control in Japanese Patients With Type 2 Diabetes: A Pilot Study
BACKGROUND: Patients with type 2 diabetes mellitus often take multiple anti-diabetic drugs for a long period. Fixed dose combination (FDC) therapy is expected to improve drug adherence for patients with diabetes. The effect of switching from a loose dose combination (LDC) regimen to an FDC regimen a...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505309/ https://www.ncbi.nlm.nih.gov/pubmed/28725321 http://dx.doi.org/10.14740/jocmr3067w |
_version_ | 1783249443916611584 |
---|---|
author | Aoki, Kazutaka Nagakura, Mieko Taguri, Masataka Kamiyama, Hiroshi Masumura, Makoto Furuie, Tadashi Oka, Masanao Kamiko, Kazunari Nakajima, Shigeru Akema, Noriko Terauchi, Yasuo |
author_facet | Aoki, Kazutaka Nagakura, Mieko Taguri, Masataka Kamiyama, Hiroshi Masumura, Makoto Furuie, Tadashi Oka, Masanao Kamiko, Kazunari Nakajima, Shigeru Akema, Noriko Terauchi, Yasuo |
author_sort | Aoki, Kazutaka |
collection | PubMed |
description | BACKGROUND: Patients with type 2 diabetes mellitus often take multiple anti-diabetic drugs for a long period. Fixed dose combination (FDC) therapy is expected to improve drug adherence for patients with diabetes. The effect of switching from a loose dose combination (LDC) regimen to an FDC regimen at equivalent dosage on glycemic control has not been evaluated fully. Therefore, we investigated the effect of switching from LDC to FDC at equivalent dosage for 6 months on glycemic control in Japanese patients with type 2 diabetes. METHODS: Thirty-eight Japanese patients with type 2 diabetes who were taking anti-diabetic drugs including pioglitazone + metformin, pioglitazone + alogliptin, or pioglitazone + glimepiride were enrolled. These drugs were switched to an FDC of Metact(®), Liobel(®) or Sonias(®), respectively, at equivalent dosage. Other anti-diabetic drugs and units of insulin were not changed during the study if possible. HbA1c and body weight were measured 0, 2, 4 and 6 months after switching from an LDC to FDC. We also conducted a questionnaire survey 2 months after the start of the FDC regimen. RESULTS: HbA1c levels at 2, 4, and 6 months were not significantly changed compared with prior to switching from an LDC to FDC regimen. Moreover, 74.2% of patients considered decreasing the number of drugs to be “very good” or “good”. CONCLUSION: HbA1c levels did not differ between patients receiving LDC and FDC therapy at equivalent dosage in this study. |
format | Online Article Text |
id | pubmed-5505309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-55053092017-07-19 Effect of Switching From an Anti-Diabetic Loose Dose Combination to a Fixed Dose Combination Regimen at Equivalent Dosage for 6 Months on Glycemic Control in Japanese Patients With Type 2 Diabetes: A Pilot Study Aoki, Kazutaka Nagakura, Mieko Taguri, Masataka Kamiyama, Hiroshi Masumura, Makoto Furuie, Tadashi Oka, Masanao Kamiko, Kazunari Nakajima, Shigeru Akema, Noriko Terauchi, Yasuo J Clin Med Res Short Communication BACKGROUND: Patients with type 2 diabetes mellitus often take multiple anti-diabetic drugs for a long period. Fixed dose combination (FDC) therapy is expected to improve drug adherence for patients with diabetes. The effect of switching from a loose dose combination (LDC) regimen to an FDC regimen at equivalent dosage on glycemic control has not been evaluated fully. Therefore, we investigated the effect of switching from LDC to FDC at equivalent dosage for 6 months on glycemic control in Japanese patients with type 2 diabetes. METHODS: Thirty-eight Japanese patients with type 2 diabetes who were taking anti-diabetic drugs including pioglitazone + metformin, pioglitazone + alogliptin, or pioglitazone + glimepiride were enrolled. These drugs were switched to an FDC of Metact(®), Liobel(®) or Sonias(®), respectively, at equivalent dosage. Other anti-diabetic drugs and units of insulin were not changed during the study if possible. HbA1c and body weight were measured 0, 2, 4 and 6 months after switching from an LDC to FDC. We also conducted a questionnaire survey 2 months after the start of the FDC regimen. RESULTS: HbA1c levels at 2, 4, and 6 months were not significantly changed compared with prior to switching from an LDC to FDC regimen. Moreover, 74.2% of patients considered decreasing the number of drugs to be “very good” or “good”. CONCLUSION: HbA1c levels did not differ between patients receiving LDC and FDC therapy at equivalent dosage in this study. Elmer Press 2017-08 2017-07-01 /pmc/articles/PMC5505309/ /pubmed/28725321 http://dx.doi.org/10.14740/jocmr3067w Text en Copyright 2017, Aoki et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Aoki, Kazutaka Nagakura, Mieko Taguri, Masataka Kamiyama, Hiroshi Masumura, Makoto Furuie, Tadashi Oka, Masanao Kamiko, Kazunari Nakajima, Shigeru Akema, Noriko Terauchi, Yasuo Effect of Switching From an Anti-Diabetic Loose Dose Combination to a Fixed Dose Combination Regimen at Equivalent Dosage for 6 Months on Glycemic Control in Japanese Patients With Type 2 Diabetes: A Pilot Study |
title | Effect of Switching From an Anti-Diabetic Loose Dose Combination to a Fixed Dose Combination Regimen at Equivalent Dosage for 6 Months on Glycemic Control in Japanese Patients With Type 2 Diabetes: A Pilot Study |
title_full | Effect of Switching From an Anti-Diabetic Loose Dose Combination to a Fixed Dose Combination Regimen at Equivalent Dosage for 6 Months on Glycemic Control in Japanese Patients With Type 2 Diabetes: A Pilot Study |
title_fullStr | Effect of Switching From an Anti-Diabetic Loose Dose Combination to a Fixed Dose Combination Regimen at Equivalent Dosage for 6 Months on Glycemic Control in Japanese Patients With Type 2 Diabetes: A Pilot Study |
title_full_unstemmed | Effect of Switching From an Anti-Diabetic Loose Dose Combination to a Fixed Dose Combination Regimen at Equivalent Dosage for 6 Months on Glycemic Control in Japanese Patients With Type 2 Diabetes: A Pilot Study |
title_short | Effect of Switching From an Anti-Diabetic Loose Dose Combination to a Fixed Dose Combination Regimen at Equivalent Dosage for 6 Months on Glycemic Control in Japanese Patients With Type 2 Diabetes: A Pilot Study |
title_sort | effect of switching from an anti-diabetic loose dose combination to a fixed dose combination regimen at equivalent dosage for 6 months on glycemic control in japanese patients with type 2 diabetes: a pilot study |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505309/ https://www.ncbi.nlm.nih.gov/pubmed/28725321 http://dx.doi.org/10.14740/jocmr3067w |
work_keys_str_mv | AT aokikazutaka effectofswitchingfromanantidiabeticloosedosecombinationtoafixeddosecombinationregimenatequivalentdosagefor6monthsonglycemiccontrolinjapanesepatientswithtype2diabetesapilotstudy AT nagakuramieko effectofswitchingfromanantidiabeticloosedosecombinationtoafixeddosecombinationregimenatequivalentdosagefor6monthsonglycemiccontrolinjapanesepatientswithtype2diabetesapilotstudy AT tagurimasataka effectofswitchingfromanantidiabeticloosedosecombinationtoafixeddosecombinationregimenatequivalentdosagefor6monthsonglycemiccontrolinjapanesepatientswithtype2diabetesapilotstudy AT kamiyamahiroshi effectofswitchingfromanantidiabeticloosedosecombinationtoafixeddosecombinationregimenatequivalentdosagefor6monthsonglycemiccontrolinjapanesepatientswithtype2diabetesapilotstudy AT masumuramakoto effectofswitchingfromanantidiabeticloosedosecombinationtoafixeddosecombinationregimenatequivalentdosagefor6monthsonglycemiccontrolinjapanesepatientswithtype2diabetesapilotstudy AT furuietadashi effectofswitchingfromanantidiabeticloosedosecombinationtoafixeddosecombinationregimenatequivalentdosagefor6monthsonglycemiccontrolinjapanesepatientswithtype2diabetesapilotstudy AT okamasanao effectofswitchingfromanantidiabeticloosedosecombinationtoafixeddosecombinationregimenatequivalentdosagefor6monthsonglycemiccontrolinjapanesepatientswithtype2diabetesapilotstudy AT kamikokazunari effectofswitchingfromanantidiabeticloosedosecombinationtoafixeddosecombinationregimenatequivalentdosagefor6monthsonglycemiccontrolinjapanesepatientswithtype2diabetesapilotstudy AT nakajimashigeru effectofswitchingfromanantidiabeticloosedosecombinationtoafixeddosecombinationregimenatequivalentdosagefor6monthsonglycemiccontrolinjapanesepatientswithtype2diabetesapilotstudy AT akemanoriko effectofswitchingfromanantidiabeticloosedosecombinationtoafixeddosecombinationregimenatequivalentdosagefor6monthsonglycemiccontrolinjapanesepatientswithtype2diabetesapilotstudy AT terauchiyasuo effectofswitchingfromanantidiabeticloosedosecombinationtoafixeddosecombinationregimenatequivalentdosagefor6monthsonglycemiccontrolinjapanesepatientswithtype2diabetesapilotstudy |