ACETYL-COA SYNTHETASE REGULATES HISTONE ACETYLATION AND HIPPOCAMPAL MEMORY

Metabolic production of acetyl-CoA is linked to histone acetylation and gene regulation, yet the precise mechanisms are largely unknown. Here we show that the metabolic enzyme acetyl-CoA synthetase 2 (ACSS2) is a direct regulator of histone acetylation in neurons and of spatial memory in mammals. In...

Descripción completa

Detalles Bibliográficos
Autores principales: Mews, Philipp, Donahue, Greg, Drake, Adam M., Luczak, Vincent, Abel, Ted, Berger, Shelley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505514/
https://www.ncbi.nlm.nih.gov/pubmed/28562591
http://dx.doi.org/10.1038/nature22405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505514/
https://www.ncbi.nlm.nih.gov/pubmed/28562591
http://dx.doi.org/10.1038/nature22405

Ejemplares similares