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ACETYL-COA SYNTHETASE REGULATES HISTONE ACETYLATION AND HIPPOCAMPAL MEMORY

Metabolic production of acetyl-CoA is linked to histone acetylation and gene regulation, yet the precise mechanisms are largely unknown. Here we show that the metabolic enzyme acetyl-CoA synthetase 2 (ACSS2) is a direct regulator of histone acetylation in neurons and of spatial memory in mammals. In...

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Detalles Bibliográficos
Autores principales:	Mews, Philipp, Donahue, Greg, Drake, Adam M., Luczak, Vincent, Abel, Ted, Berger, Shelley L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505514/ https://www.ncbi.nlm.nih.gov/pubmed/28562591 http://dx.doi.org/10.1038/nature22405

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