Comparison of a mouse and a novel human scFv-SNAP-auristatin F drug conjugate with potent activity against EGFR-overexpressing human solid tumor cells

Antibody–drug conjugates (ADCs) can deliver toxins to specific targets such as tumor cells. They have shown promise in preclinical/clinical development but feature stoichiometrically undefined chemical linkages, and those based on full-size antibodies achieve only limited tumor penetration. SNAP-tag...

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Detalles Bibliográficos
Autores principales: Woitok, Mira, Klose, Diana, Di Fiore, Stefano, Richter, Wolfgang, Stein, Christoph, Gresch, Gerrit, Grieger, Elena, Barth, Stefan, Fischer, Rainer, Kolberg, Katharina, Niesen, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505605/
https://www.ncbi.nlm.nih.gov/pubmed/28740407
http://dx.doi.org/10.2147/OTT.S140492

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