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Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan

OBJECTIVE: Lifestyle changes may play an important role in the incidence reduction and delay of onset age of amyotrophic lateral sclerosis (ALS) in the Koza/Kozagawa/Kushimoto (K) area. The aim of this study was to evaluate recent lifestyle changes in the K area and to investigate the relationships...

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Autores principales: Kihira, Tameko, Okamoto, Kazushi, Sakurai, Iori, Arakawa, Yuya, Wakayama, Ikuro, Takamiya, Koichi, Okumura, Ryo, Iinuma, Yuhto, Iwai, Keiko, Kokubo, Yasumasa, Yoshida, Sohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505904/
https://www.ncbi.nlm.nih.gov/pubmed/28626174
http://dx.doi.org/10.2169/internalmedicine.56.8038
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author Kihira, Tameko
Okamoto, Kazushi
Sakurai, Iori
Arakawa, Yuya
Wakayama, Ikuro
Takamiya, Koichi
Okumura, Ryo
Iinuma, Yuhto
Iwai, Keiko
Kokubo, Yasumasa
Yoshida, Sohei
author_facet Kihira, Tameko
Okamoto, Kazushi
Sakurai, Iori
Arakawa, Yuya
Wakayama, Ikuro
Takamiya, Koichi
Okumura, Ryo
Iinuma, Yuhto
Iwai, Keiko
Kokubo, Yasumasa
Yoshida, Sohei
author_sort Kihira, Tameko
collection PubMed
description OBJECTIVE: Lifestyle changes may play an important role in the incidence reduction and delay of onset age of amyotrophic lateral sclerosis (ALS) in the Koza/Kozagawa/Kushimoto (K) area. The aim of this study was to evaluate recent lifestyle changes in the K area and to investigate the relationships between lifestyle and oxidative stress among the residents. METHODS: We conducted a medical checkup for elderly residents in the K area and the control area and evaluated the urinary 8-OHdG levels, cognitive function test scores and metal contents in serum and scalp hair, coupled with a lifestyle questionnaire survey between 2010 and 2015. RESULTS: Recent lifestyle changes among the K residents, including a decrease in the Japanese pickle consumption, increase in fresh vegetable consumption and decrease in farm work, were evaluated in this study. Low consumption of Japanese pickles, high consumption of fresh vegetables, rare farm work and low levels of 8-OHdG/creatinine were all associated with high scores in the cognitive function tests. Frequent farm work and consumption of Japanese pickles was associated with high contents of transition metals, such as Mn, Al and V, in the scalp hair. CONCLUSION: These lifestyle changes among residents in the K area may be associated with their oxidative stress.
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spelling pubmed-55059042017-07-14 Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan Kihira, Tameko Okamoto, Kazushi Sakurai, Iori Arakawa, Yuya Wakayama, Ikuro Takamiya, Koichi Okumura, Ryo Iinuma, Yuhto Iwai, Keiko Kokubo, Yasumasa Yoshida, Sohei Intern Med Original Article OBJECTIVE: Lifestyle changes may play an important role in the incidence reduction and delay of onset age of amyotrophic lateral sclerosis (ALS) in the Koza/Kozagawa/Kushimoto (K) area. The aim of this study was to evaluate recent lifestyle changes in the K area and to investigate the relationships between lifestyle and oxidative stress among the residents. METHODS: We conducted a medical checkup for elderly residents in the K area and the control area and evaluated the urinary 8-OHdG levels, cognitive function test scores and metal contents in serum and scalp hair, coupled with a lifestyle questionnaire survey between 2010 and 2015. RESULTS: Recent lifestyle changes among the K residents, including a decrease in the Japanese pickle consumption, increase in fresh vegetable consumption and decrease in farm work, were evaluated in this study. Low consumption of Japanese pickles, high consumption of fresh vegetables, rare farm work and low levels of 8-OHdG/creatinine were all associated with high scores in the cognitive function tests. Frequent farm work and consumption of Japanese pickles was associated with high contents of transition metals, such as Mn, Al and V, in the scalp hair. CONCLUSION: These lifestyle changes among residents in the K area may be associated with their oxidative stress. The Japanese Society of Internal Medicine 2017-06-15 /pmc/articles/PMC5505904/ /pubmed/28626174 http://dx.doi.org/10.2169/internalmedicine.56.8038 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Kihira, Tameko
Okamoto, Kazushi
Sakurai, Iori
Arakawa, Yuya
Wakayama, Ikuro
Takamiya, Koichi
Okumura, Ryo
Iinuma, Yuhto
Iwai, Keiko
Kokubo, Yasumasa
Yoshida, Sohei
Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan
title Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan
title_full Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan
title_fullStr Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan
title_full_unstemmed Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan
title_short Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan
title_sort lifestyle changes and oxidative stress in a high-incidence area of amyotrophic lateral sclerosis in the southwestern kii peninsula, japan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505904/
https://www.ncbi.nlm.nih.gov/pubmed/28626174
http://dx.doi.org/10.2169/internalmedicine.56.8038
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