Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects

Succinic acid cibenzoline (CZ) is an antiarrhythmic agent often used for the treatment of tachyarrhythmia. However, hypoglycemia should be avoided in the treatment of diabetes. We herein report two late-stage elderly subjects who experienced a severe and prolonged hypoglycemic coma after the usage o...

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Autores principales: Hirata, Yurie, Kamei, Shinji, Tatsumi, Fuminori, Shimoda, Masashi, Tanabe, Akihito, Sanada, Junpei, Fushimi, Yoshiro, Irie, Shintaro, Mune, Tomoatsu, Kaku, Kohei, Kaneto, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505908/
https://www.ncbi.nlm.nih.gov/pubmed/28626178
http://dx.doi.org/10.2169/internalmedicine.56.8120
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author Hirata, Yurie
Kamei, Shinji
Tatsumi, Fuminori
Shimoda, Masashi
Tanabe, Akihito
Sanada, Junpei
Fushimi, Yoshiro
Irie, Shintaro
Mune, Tomoatsu
Kaku, Kohei
Kaneto, Hideaki
author_facet Hirata, Yurie
Kamei, Shinji
Tatsumi, Fuminori
Shimoda, Masashi
Tanabe, Akihito
Sanada, Junpei
Fushimi, Yoshiro
Irie, Shintaro
Mune, Tomoatsu
Kaku, Kohei
Kaneto, Hideaki
author_sort Hirata, Yurie
collection PubMed
description Succinic acid cibenzoline (CZ) is an antiarrhythmic agent often used for the treatment of tachyarrhythmia. However, hypoglycemia should be avoided in the treatment of diabetes. We herein report two late-stage elderly subjects who experienced a severe and prolonged hypoglycemic coma after the usage of CZ. These cases suggest that, when CZ is administered to elderly subjects with renal dysfunction and/or frailty, we should be aware of the possibility that this medicine may induce hypoglycemia and should adjust the dose as appropriate and monitor the concentration of CZ to avoid severe hypoglycemia.
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spelling pubmed-55059082017-07-14 Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects Hirata, Yurie Kamei, Shinji Tatsumi, Fuminori Shimoda, Masashi Tanabe, Akihito Sanada, Junpei Fushimi, Yoshiro Irie, Shintaro Mune, Tomoatsu Kaku, Kohei Kaneto, Hideaki Intern Med Case Report Succinic acid cibenzoline (CZ) is an antiarrhythmic agent often used for the treatment of tachyarrhythmia. However, hypoglycemia should be avoided in the treatment of diabetes. We herein report two late-stage elderly subjects who experienced a severe and prolonged hypoglycemic coma after the usage of CZ. These cases suggest that, when CZ is administered to elderly subjects with renal dysfunction and/or frailty, we should be aware of the possibility that this medicine may induce hypoglycemia and should adjust the dose as appropriate and monitor the concentration of CZ to avoid severe hypoglycemia. The Japanese Society of Internal Medicine 2017-06-15 /pmc/articles/PMC5505908/ /pubmed/28626178 http://dx.doi.org/10.2169/internalmedicine.56.8120 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hirata, Yurie
Kamei, Shinji
Tatsumi, Fuminori
Shimoda, Masashi
Tanabe, Akihito
Sanada, Junpei
Fushimi, Yoshiro
Irie, Shintaro
Mune, Tomoatsu
Kaku, Kohei
Kaneto, Hideaki
Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects
title Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects
title_full Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects
title_fullStr Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects
title_full_unstemmed Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects
title_short Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects
title_sort hypoglycemic coma induced by the use of succinic acid cibenzoline in frail late-stage elderly subjects
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505908/
https://www.ncbi.nlm.nih.gov/pubmed/28626178
http://dx.doi.org/10.2169/internalmedicine.56.8120
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