Long-term Low-density Lipoprotein Apheresis in a Patient with Refractory Idiopathic Membranous Glomerulonephritis

A 61-year-old Japanese man developed nephrotic syndrome (NS) due to idiopathic membranous glomerulonephritis (MGN). He received immunosuppressive therapy for two years, including prednisolone, cyclophosphamide, and cyclosporine A, but the NS persisted. Low-density lipoprotein apheresis (LDL-A) was i...

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Detalles Bibliográficos
Autores principales: Yabuuchi, Junko, Suwabe, Tatsuya, Mizuno, Hiroki, Ueno, Toshiharu, Hoshino, Junichi, Sekine, Akinari, Kawada, Masahiro, Yamanouchi, Masayuki, Hayami, Noriko, Hiramatsu, Rikako, Hasegawa, Eiko, Sawa, Naoki, Takaichi, Kenmei, Fujii, Takeshi, Ohashi, Kenichi, Ubara, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505911/
https://www.ncbi.nlm.nih.gov/pubmed/28626181
http://dx.doi.org/10.2169/internalmedicine.56.8081
Descripción
Sumario:A 61-year-old Japanese man developed nephrotic syndrome (NS) due to idiopathic membranous glomerulonephritis (MGN). He received immunosuppressive therapy for two years, including prednisolone, cyclophosphamide, and cyclosporine A, but the NS persisted. Low-density lipoprotein apheresis (LDL-A) was initiated at a frequency of twice a month and continued for 9 years (203 sessions in total). His proteinuria reduced to less than 1 g daily after 9 years. LDL-A was stopped, and the NS has not relapsed for five years. This case suggests that long-term LDL-A therapy may be a treatment option for idiopathic MGN refractory to immunosuppressive therapy or short-term LDL-A.

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