Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome

A 35-year-old woman with discoid lupus erythematosus (DLE) was admitted at 11 weeks' gestation with a persistent fever. Laboratory studies revealed pancytopenia, elevated liver enzymes, and hyperferritinemia. Bone marrow aspiration confirmed the diagnosis of hemophagocytic syndrome (HPS). She h...

Descripción completa

Detalles Bibliográficos
Autores principales: Takada, Hideto, Kimura, Naoki, Yoshihashi-Nakazato, Yoko, Kawahata, Kimito, Kohsaka, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505918/
https://www.ncbi.nlm.nih.gov/pubmed/28626188
http://dx.doi.org/10.2169/internalmedicine.56.8156
_version_ 1783249485201145856
author Takada, Hideto
Kimura, Naoki
Yoshihashi-Nakazato, Yoko
Kawahata, Kimito
Kohsaka, Hitoshi
author_facet Takada, Hideto
Kimura, Naoki
Yoshihashi-Nakazato, Yoko
Kawahata, Kimito
Kohsaka, Hitoshi
author_sort Takada, Hideto
collection PubMed
description A 35-year-old woman with discoid lupus erythematosus (DLE) was admitted at 11 weeks' gestation with a persistent fever. Laboratory studies revealed pancytopenia, elevated liver enzymes, and hyperferritinemia. Bone marrow aspiration confirmed the diagnosis of hemophagocytic syndrome (HPS). She had no findings of infection or active systemic lupus erythematosus. The administration of high-dose corticosteroids resolved the clinical and laboratory findings. She delivered a healthy baby at 35 weeks' gestation. This case suggests that DLE can be a predisposing factor for pregnancy-induced HPS.
format Online
Article
Text
id pubmed-5505918
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-55059182017-07-14 Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome Takada, Hideto Kimura, Naoki Yoshihashi-Nakazato, Yoko Kawahata, Kimito Kohsaka, Hitoshi Intern Med Case Report A 35-year-old woman with discoid lupus erythematosus (DLE) was admitted at 11 weeks' gestation with a persistent fever. Laboratory studies revealed pancytopenia, elevated liver enzymes, and hyperferritinemia. Bone marrow aspiration confirmed the diagnosis of hemophagocytic syndrome (HPS). She had no findings of infection or active systemic lupus erythematosus. The administration of high-dose corticosteroids resolved the clinical and laboratory findings. She delivered a healthy baby at 35 weeks' gestation. This case suggests that DLE can be a predisposing factor for pregnancy-induced HPS. The Japanese Society of Internal Medicine 2017-06-15 /pmc/articles/PMC5505918/ /pubmed/28626188 http://dx.doi.org/10.2169/internalmedicine.56.8156 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Takada, Hideto
Kimura, Naoki
Yoshihashi-Nakazato, Yoko
Kawahata, Kimito
Kohsaka, Hitoshi
Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome
title Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome
title_full Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome
title_fullStr Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome
title_full_unstemmed Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome
title_short Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome
title_sort discoid lupus erythematosus complicated with pregnancy-induced hemophagocytic syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505918/
https://www.ncbi.nlm.nih.gov/pubmed/28626188
http://dx.doi.org/10.2169/internalmedicine.56.8156
work_keys_str_mv AT takadahideto discoidlupuserythematosuscomplicatedwithpregnancyinducedhemophagocyticsyndrome
AT kimuranaoki discoidlupuserythematosuscomplicatedwithpregnancyinducedhemophagocyticsyndrome
AT yoshihashinakazatoyoko discoidlupuserythematosuscomplicatedwithpregnancyinducedhemophagocyticsyndrome
AT kawahatakimito discoidlupuserythematosuscomplicatedwithpregnancyinducedhemophagocyticsyndrome
AT kohsakahitoshi discoidlupuserythematosuscomplicatedwithpregnancyinducedhemophagocyticsyndrome

Ejemplares similares