Miliary Tuberculosis in a Young Woman with Hemophagocytic Syndrome: A Case Report and Literature Review

We herein report a rare case of miliary tuberculosis-associated hemophagocytic syndrome (HPS) complicated with respiratory failure. A 19-year-old Japanese woman with a fever, general malaise, and chest radiograph abnormalities was referred to our hospital. After admission, she developed respiratory...

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Detalles Bibliográficos
Autores principales: Asaji, Mina, Tobino, Kazunori, Murakami, Koujin, Goto, Yuki, Sueyasu, Takuto, Nishizawa, Saori, Yoshimine, Kohei, Munechika, Miyuki, Ko, Yuki, Yoshimatsu, Yuki, Tsuruno, Kosuke, Ide, Hiromi, Miyajima, Hiroyuki, Ebi, Noriyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505920/
https://www.ncbi.nlm.nih.gov/pubmed/28626190
http://dx.doi.org/10.2169/internalmedicine.56.8025
Descripción
Sumario:We herein report a rare case of miliary tuberculosis-associated hemophagocytic syndrome (HPS) complicated with respiratory failure. A 19-year-old Japanese woman with a fever, general malaise, and chest radiograph abnormalities was referred to our hospital. After admission, she developed respiratory failure with pancytopenia. A histological examination of lung and bone marrow biopsy samples revealed noncaseating granulomas without evidence of acid-fast bacilli or lymphoma. In addition, a bone marrow biopsy showed marked histiocyte hyperplasia with hemophagocytosis, and a bronchoalveolar lavage fluid culture grew Mycobacterium tuberculosis. Therefore, a diagnosis of miliary tuberculosis-associated HPS was made. The patient was successfully treated with antituberculous therapy.

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