Comparing sequencing assays and human-machine analyses in actionable genomics for glioblastoma

OBJECTIVE: To analyze a glioblastoma tumor specimen with 3 different platforms and compare potentially actionable calls from each. METHODS: Tumor DNA was analyzed by a commercial targeted panel. In addition, tumor-normal DNA was analyzed by whole-genome sequencing (WGS) and tumor RNA was analyzed by...

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Detalles Bibliográficos
Autores principales: Wrzeszczynski, Kazimierz O., Frank, Mayu O., Koyama, Takahiko, Rhrissorrakrai, Kahn, Robine, Nicolas, Utro, Filippo, Emde, Anne-Katrin, Chen, Bo-Juen, Arora, Kanika, Shah, Minita, Vacic, Vladimir, Norel, Raquel, Bilal, Erhan, Bergmann, Ewa A., Moore Vogel, Julia L., Bruce, Jeffrey N., Lassman, Andrew B., Canoll, Peter, Grommes, Christian, Harvey, Steve, Parida, Laxmi, Michelini, Vanessa V., Zody, Michael C., Jobanputra, Vaidehi, Royyuru, Ajay K., Darnell, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506390/
https://www.ncbi.nlm.nih.gov/pubmed/28740869
http://dx.doi.org/10.1212/NXG.0000000000000164

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