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The replicative lifespan‐extending deletion of SGF73 results in altered ribosomal gene expression in yeast

Sgf73, a core component of SAGA, is the yeast orthologue of ataxin‐7, which undergoes CAG–polyglutamine repeat expansion leading to the human neurodegenerative disease spinocerebellar ataxia type 7 (SCA7). Deletion of SGF73 dramatically extends replicative lifespan (RLS) in yeast. To further define...

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Detalles Bibliográficos
Autores principales:	Mason, Amanda G., Garza, Renee M., McCormick, Mark A., Patel, Bhumil, Kennedy, Brian K., Pillus, Lorraine, La Spada, Albert R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506417/ https://www.ncbi.nlm.nih.gov/pubmed/28568901 http://dx.doi.org/10.1111/acel.12611

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