Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity

We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age. We find substantial enrichment in genes for which knockdown increased lifespan. This enrichment is markedly higher than published genomewide l...

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Detalles Bibliográficos
Autores principales: Sutphin, George L., Backer, Grant, Sheehan, Susan, Bean, Shannon, Corban, Caroline, Liu, Teresa, Peters, Marjolein J., van Meurs, Joyce B. J., Murabito, Joanne M., Johnson, Andrew D., Korstanje, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506438/
https://www.ncbi.nlm.nih.gov/pubmed/28401650
http://dx.doi.org/10.1111/acel.12595

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