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Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases

In Tenosynovial Giant Cell Tumours (TGCT), previously named Pigmented Villonodular Synovitis (PVNS), a distinction is made between a single nodule (localized-type) and multiple nodules (diffuse-type). Diffuse-type is considered locally aggressive. Onset and extermination of this orphan disease remai...

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Autores principales: Mastboom, Monique J. L., Verspoor, Floortje G. M., Gelderblom, Hans, van de Sande, Michiel A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506462/
https://www.ncbi.nlm.nih.gov/pubmed/28744388
http://dx.doi.org/10.1155/2017/7402570
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author Mastboom, Monique J. L.
Verspoor, Floortje G. M.
Gelderblom, Hans
van de Sande, Michiel A. J.
author_facet Mastboom, Monique J. L.
Verspoor, Floortje G. M.
Gelderblom, Hans
van de Sande, Michiel A. J.
author_sort Mastboom, Monique J. L.
collection PubMed
description In Tenosynovial Giant Cell Tumours (TGCT), previously named Pigmented Villonodular Synovitis (PVNS), a distinction is made between a single nodule (localized-type) and multiple nodules (diffuse-type). Diffuse-type is considered locally aggressive. Onset and extermination of this orphan disease remain unclear. Surgical resection is the most commonly performed treatment. Unfortunately, recurrences often occur (up to 92%), necessitating reoperations and adjuvant treatments. Once all treatments fail or if severe complications occur, limb amputation may become unavoidable. We describe four cases of above-knee amputation after TGCT diagnosis.
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spelling pubmed-55064622017-07-25 Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases Mastboom, Monique J. L. Verspoor, Floortje G. M. Gelderblom, Hans van de Sande, Michiel A. J. Case Rep Orthop Case Report In Tenosynovial Giant Cell Tumours (TGCT), previously named Pigmented Villonodular Synovitis (PVNS), a distinction is made between a single nodule (localized-type) and multiple nodules (diffuse-type). Diffuse-type is considered locally aggressive. Onset and extermination of this orphan disease remain unclear. Surgical resection is the most commonly performed treatment. Unfortunately, recurrences often occur (up to 92%), necessitating reoperations and adjuvant treatments. Once all treatments fail or if severe complications occur, limb amputation may become unavoidable. We describe four cases of above-knee amputation after TGCT diagnosis. Hindawi 2017 2017-06-28 /pmc/articles/PMC5506462/ /pubmed/28744388 http://dx.doi.org/10.1155/2017/7402570 Text en Copyright © 2017 Monique J. L. Mastboom et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mastboom, Monique J. L.
Verspoor, Floortje G. M.
Gelderblom, Hans
van de Sande, Michiel A. J.
Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases
title Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases
title_full Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases
title_fullStr Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases
title_full_unstemmed Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases
title_short Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases
title_sort limb amputation after multiple treatments of tenosynovial giant cell tumour: series of 4 dutch cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506462/
https://www.ncbi.nlm.nih.gov/pubmed/28744388
http://dx.doi.org/10.1155/2017/7402570
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