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Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases
In Tenosynovial Giant Cell Tumours (TGCT), previously named Pigmented Villonodular Synovitis (PVNS), a distinction is made between a single nodule (localized-type) and multiple nodules (diffuse-type). Diffuse-type is considered locally aggressive. Onset and extermination of this orphan disease remai...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506462/ https://www.ncbi.nlm.nih.gov/pubmed/28744388 http://dx.doi.org/10.1155/2017/7402570 |
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author | Mastboom, Monique J. L. Verspoor, Floortje G. M. Gelderblom, Hans van de Sande, Michiel A. J. |
author_facet | Mastboom, Monique J. L. Verspoor, Floortje G. M. Gelderblom, Hans van de Sande, Michiel A. J. |
author_sort | Mastboom, Monique J. L. |
collection | PubMed |
description | In Tenosynovial Giant Cell Tumours (TGCT), previously named Pigmented Villonodular Synovitis (PVNS), a distinction is made between a single nodule (localized-type) and multiple nodules (diffuse-type). Diffuse-type is considered locally aggressive. Onset and extermination of this orphan disease remain unclear. Surgical resection is the most commonly performed treatment. Unfortunately, recurrences often occur (up to 92%), necessitating reoperations and adjuvant treatments. Once all treatments fail or if severe complications occur, limb amputation may become unavoidable. We describe four cases of above-knee amputation after TGCT diagnosis. |
format | Online Article Text |
id | pubmed-5506462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-55064622017-07-25 Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases Mastboom, Monique J. L. Verspoor, Floortje G. M. Gelderblom, Hans van de Sande, Michiel A. J. Case Rep Orthop Case Report In Tenosynovial Giant Cell Tumours (TGCT), previously named Pigmented Villonodular Synovitis (PVNS), a distinction is made between a single nodule (localized-type) and multiple nodules (diffuse-type). Diffuse-type is considered locally aggressive. Onset and extermination of this orphan disease remain unclear. Surgical resection is the most commonly performed treatment. Unfortunately, recurrences often occur (up to 92%), necessitating reoperations and adjuvant treatments. Once all treatments fail or if severe complications occur, limb amputation may become unavoidable. We describe four cases of above-knee amputation after TGCT diagnosis. Hindawi 2017 2017-06-28 /pmc/articles/PMC5506462/ /pubmed/28744388 http://dx.doi.org/10.1155/2017/7402570 Text en Copyright © 2017 Monique J. L. Mastboom et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Mastboom, Monique J. L. Verspoor, Floortje G. M. Gelderblom, Hans van de Sande, Michiel A. J. Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases |
title | Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases |
title_full | Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases |
title_fullStr | Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases |
title_full_unstemmed | Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases |
title_short | Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases |
title_sort | limb amputation after multiple treatments of tenosynovial giant cell tumour: series of 4 dutch cases |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506462/ https://www.ncbi.nlm.nih.gov/pubmed/28744388 http://dx.doi.org/10.1155/2017/7402570 |
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