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Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections
BACKGROUND: Whether viral coinfections cause more severe disease than Bordetella pertussis (B. pertussis) alone remains unclear. We compared clinical disease severity and sought clinical and demographic differences between infants with B. pertussis infection alone and those with respiratory viral co...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506634/ https://www.ncbi.nlm.nih.gov/pubmed/28701160 http://dx.doi.org/10.1186/s12879-017-2567-6 |
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author | Frassanito, A. Nenna, R. Nicolai, A. Pierangeli, A. Tozzi, A. E. Stefanelli, P. Carsetti, R. Concato, C. Schiavoni, I. Midulla, F. |
author_facet | Frassanito, A. Nenna, R. Nicolai, A. Pierangeli, A. Tozzi, A. E. Stefanelli, P. Carsetti, R. Concato, C. Schiavoni, I. Midulla, F. |
author_sort | Frassanito, A. |
collection | PubMed |
description | BACKGROUND: Whether viral coinfections cause more severe disease than Bordetella pertussis (B. pertussis) alone remains unclear. We compared clinical disease severity and sought clinical and demographic differences between infants with B. pertussis infection alone and those with respiratory viral coinfections. We also analyzed how respiratory infections were distributed during the 2 years study. METHODS: We enrolled 53 infants with pertussis younger than 180 days (median age 58 days, range 17–109 days, 64.1% boys), hospitalized in the Pediatric Departments at “Sapienza” University Rome and Bambino Gesù Children’s Hospital from August 2012 to November 2014. We tested in naso-pharyngeal washings B. pertussis and 14 respiratory viruses with real-time reverse-transcriptase-polymerase chain reaction. Clinical data were obtained from hospital records and demographic characteristics collected using a structured questionnaire. RESULTS: 28/53 infants had B. pertussis alone and 25 viral coinfection: 10 human rhinovirus (9 alone and 1 in coinfection with parainfluenza virus), 3 human coronavirus, 2 respiratory syncytial virus. No differences were observed in clinical disease severity between infants with B. pertussis infection alone and those with coinfections. Infants with B. pertussis alone were younger than infants with coinfections, and less often breastfeed at admission. CONCLUSIONS: In this descriptive study, no associations between clinical severity and pertussis with or without co-infections were found. TRIAL REGISTRATION: Policlinico Umberto I: protocol 213/14, 3085/13.02.2014, retrospectively registered. Bambino Gesù Children’s Hospital: protocol n. RF-2010-2317709. |
format | Online Article Text |
id | pubmed-5506634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-55066342017-07-13 Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections Frassanito, A. Nenna, R. Nicolai, A. Pierangeli, A. Tozzi, A. E. Stefanelli, P. Carsetti, R. Concato, C. Schiavoni, I. Midulla, F. BMC Infect Dis Research Article BACKGROUND: Whether viral coinfections cause more severe disease than Bordetella pertussis (B. pertussis) alone remains unclear. We compared clinical disease severity and sought clinical and demographic differences between infants with B. pertussis infection alone and those with respiratory viral coinfections. We also analyzed how respiratory infections were distributed during the 2 years study. METHODS: We enrolled 53 infants with pertussis younger than 180 days (median age 58 days, range 17–109 days, 64.1% boys), hospitalized in the Pediatric Departments at “Sapienza” University Rome and Bambino Gesù Children’s Hospital from August 2012 to November 2014. We tested in naso-pharyngeal washings B. pertussis and 14 respiratory viruses with real-time reverse-transcriptase-polymerase chain reaction. Clinical data were obtained from hospital records and demographic characteristics collected using a structured questionnaire. RESULTS: 28/53 infants had B. pertussis alone and 25 viral coinfection: 10 human rhinovirus (9 alone and 1 in coinfection with parainfluenza virus), 3 human coronavirus, 2 respiratory syncytial virus. No differences were observed in clinical disease severity between infants with B. pertussis infection alone and those with coinfections. Infants with B. pertussis alone were younger than infants with coinfections, and less often breastfeed at admission. CONCLUSIONS: In this descriptive study, no associations between clinical severity and pertussis with or without co-infections were found. TRIAL REGISTRATION: Policlinico Umberto I: protocol 213/14, 3085/13.02.2014, retrospectively registered. Bambino Gesù Children’s Hospital: protocol n. RF-2010-2317709. BioMed Central 2017-07-12 /pmc/articles/PMC5506634/ /pubmed/28701160 http://dx.doi.org/10.1186/s12879-017-2567-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Frassanito, A. Nenna, R. Nicolai, A. Pierangeli, A. Tozzi, A. E. Stefanelli, P. Carsetti, R. Concato, C. Schiavoni, I. Midulla, F. Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections |
title | Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections |
title_full | Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections |
title_fullStr | Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections |
title_full_unstemmed | Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections |
title_short | Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections |
title_sort | infants hospitalized for bordetella pertussis infection commonly have respiratory viral coinfections |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506634/ https://www.ncbi.nlm.nih.gov/pubmed/28701160 http://dx.doi.org/10.1186/s12879-017-2567-6 |
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