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Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b

BACKGROUND: Histone methylation patterns regulate gene expression and are highly dynamic during development. The erasure of histone methylation is carried out by histone demethylase enzymes. We had previously shown that vitamin C enhances the activity of Tet enzymes in embryonic stem (ES) cells, lea...

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Detalles Bibliográficos
Autores principales:	Ebata, Kevin T., Mesh, Kathryn, Liu, Shichong, Bilenky, Misha, Fekete, Alexander, Acker, Michael G., Hirst, Martin, Garcia, Benjamin A., Ramalho-Santos, Miguel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506665/ https://www.ncbi.nlm.nih.gov/pubmed/28706564 http://dx.doi.org/10.1186/s13072-017-0143-3

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