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New constituents triterpene ester and sugar derivatives from Panax ginseng Meyer and their evaluation of antioxidant activities

Panax ginseng C. A. Meyer (Araliaceae), is a well-known herb and used in the old established system of Oriental remedy, especially in Japan, China and Korea. Four new compounds characterized as (cis)- 7β,11α,19,21-tetra-O-decanoyl-18, 22β-dihydroxy-dammar-1-en-3-one (1), 3β,4α,12β-trihydroxystigmast...

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Autores principales: Chung, Ill-Min, Siddiqui, Nasir Ali, Kim, Seung Hyun, Nagella, Praveen, Khan, Azmat Ali, Ali, Mohd, Ahmad, Ateeque
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506737/
https://www.ncbi.nlm.nih.gov/pubmed/28725154
http://dx.doi.org/10.1016/j.jsps.2016.12.002
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author Chung, Ill-Min
Siddiqui, Nasir Ali
Kim, Seung Hyun
Nagella, Praveen
Khan, Azmat Ali
Ali, Mohd
Ahmad, Ateeque
author_facet Chung, Ill-Min
Siddiqui, Nasir Ali
Kim, Seung Hyun
Nagella, Praveen
Khan, Azmat Ali
Ali, Mohd
Ahmad, Ateeque
author_sort Chung, Ill-Min
collection PubMed
description Panax ginseng C. A. Meyer (Araliaceae), is a well-known herb and used in the old established system of Oriental remedy, especially in Japan, China and Korea. Four new compounds characterized as (cis)- 7β,11α,19,21-tetra-O-decanoyl-18, 22β-dihydroxy-dammar-1-en-3-one (1), 3β,4α,12β-trihydroxystigmast-5-en-21-yl octadecan-9′,12′-dienoate (2), dammar-12, 24-dien-3α, 6β, 15α-triol-3α-D-arabinopyranosyl-6β-L-arabinopyranoside (3) and dammar-24-en-3α, 6β, 16α, 20β-tetraol-3α-D-arabinopyranosyl-6β-D-arabinopyranoside (4) were isolated and established from the ethyl acetate and butanol extracts of the roots of P. ginseng. Their structures were established on the basis of spectral data and chemical reactions. Natural compounds indicative a great reservoir of materials and compounds with evolved biological activity, including antioxidant. Compounds 1–4 were investigated in vitro for antioxidant potential using ferric reducing antioxidant power (FRAP), the Nitric oxide (NO) scavenging activity, reducing power, phosphomolybdenum and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging actions, and the decision showed the compounds 3and 4 have probablyessential antioxidant properties than the compounds 1and 2 presented weak activity.
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spelling pubmed-55067372017-07-19 New constituents triterpene ester and sugar derivatives from Panax ginseng Meyer and their evaluation of antioxidant activities Chung, Ill-Min Siddiqui, Nasir Ali Kim, Seung Hyun Nagella, Praveen Khan, Azmat Ali Ali, Mohd Ahmad, Ateeque Saudi Pharm J Original Article Panax ginseng C. A. Meyer (Araliaceae), is a well-known herb and used in the old established system of Oriental remedy, especially in Japan, China and Korea. Four new compounds characterized as (cis)- 7β,11α,19,21-tetra-O-decanoyl-18, 22β-dihydroxy-dammar-1-en-3-one (1), 3β,4α,12β-trihydroxystigmast-5-en-21-yl octadecan-9′,12′-dienoate (2), dammar-12, 24-dien-3α, 6β, 15α-triol-3α-D-arabinopyranosyl-6β-L-arabinopyranoside (3) and dammar-24-en-3α, 6β, 16α, 20β-tetraol-3α-D-arabinopyranosyl-6β-D-arabinopyranoside (4) were isolated and established from the ethyl acetate and butanol extracts of the roots of P. ginseng. Their structures were established on the basis of spectral data and chemical reactions. Natural compounds indicative a great reservoir of materials and compounds with evolved biological activity, including antioxidant. Compounds 1–4 were investigated in vitro for antioxidant potential using ferric reducing antioxidant power (FRAP), the Nitric oxide (NO) scavenging activity, reducing power, phosphomolybdenum and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging actions, and the decision showed the compounds 3and 4 have probablyessential antioxidant properties than the compounds 1and 2 presented weak activity. Elsevier 2017-07 2016-12-24 /pmc/articles/PMC5506737/ /pubmed/28725154 http://dx.doi.org/10.1016/j.jsps.2016.12.002 Text en © 2016 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Chung, Ill-Min
Siddiqui, Nasir Ali
Kim, Seung Hyun
Nagella, Praveen
Khan, Azmat Ali
Ali, Mohd
Ahmad, Ateeque
New constituents triterpene ester and sugar derivatives from Panax ginseng Meyer and their evaluation of antioxidant activities
title New constituents triterpene ester and sugar derivatives from Panax ginseng Meyer and their evaluation of antioxidant activities
title_full New constituents triterpene ester and sugar derivatives from Panax ginseng Meyer and their evaluation of antioxidant activities
title_fullStr New constituents triterpene ester and sugar derivatives from Panax ginseng Meyer and their evaluation of antioxidant activities
title_full_unstemmed New constituents triterpene ester and sugar derivatives from Panax ginseng Meyer and their evaluation of antioxidant activities
title_short New constituents triterpene ester and sugar derivatives from Panax ginseng Meyer and their evaluation of antioxidant activities
title_sort new constituents triterpene ester and sugar derivatives from panax ginseng meyer and their evaluation of antioxidant activities
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506737/
https://www.ncbi.nlm.nih.gov/pubmed/28725154
http://dx.doi.org/10.1016/j.jsps.2016.12.002
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