Polymorphisms at activated protein C cleavage sites of factor V: Are they important in the absence of factor V Leiden?

Background: Activated protein C (APC) inactivates factor V (FV) by cleavage of its heavy chain at Arg306, Arg506, Arg679, and Lys994. Mutational changes, which abolish APC cleavage sites, may predispose thrombosis by altering the inactivation process of FV. FV Leiden (FVL) (Arg506Glu) has been demon...

Descripción completa

Detalles Bibliográficos
Autores principales: Kheradmand, Ehsan, Haghjooy-Javanmard, Shaghayegh, Dehghani, Leila, Saadatnia, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506753/
https://www.ncbi.nlm.nih.gov/pubmed/28717431

Ejemplares similares

Ejemplares similares