Cargando…

Impact and prognostic value of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scan in the evaluation of residual head and neck cancer: Single-center experience from Pakistan

BACKGROUND: Overview of clinical impact of positron emission tomography-computed tomography (PET-CT) scans in patients with head and neck carcinomas at our center. METHODS: Retrospective review of posttreatment (18)F-fluorodeoxyglucose ((18)F-FDG) PET-CT scans in patients with head and neck carcinom...

Descripción completa

Detalles Bibliográficos
Autores principales: Riaz, Saima, Bashir, Humayun, Iqbal, Hassan, Jamshed, Arif, Murtaza, Ahmad, Hussain, Raza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506818/
https://www.ncbi.nlm.nih.gov/pubmed/28702415
http://dx.doi.org/10.4103/2278-330X.208851
Descripción
Sumario:BACKGROUND: Overview of clinical impact of positron emission tomography-computed tomography (PET-CT) scans in patients with head and neck carcinomas at our center. METHODS: Retrospective review of posttreatment (18)F-fluorodeoxyglucose ((18)F-FDG) PET-CT scans in patients with head and neck carcinomas with risk of residual disease. Clinical outcome served as the reference standard. RESULTS: This study included 93 patients (65.6% males, mean age: 48.8 years ± 17.2 standard deviation) with squamous cell carcinoma as most frequent histopathology (91.4%). PET-CT scans were performed on average 6 months posttreatment. Diagnostic accuracy, positive predictive value, and negative predictive value of PET-CT for disease were found to be 88%, 88%, and 92%, respectively. A median follow-up of 24 months was available for 91 patients. Kaplan–Meier curves showed significantly higher disease-free survival with negative PET-CT as compared to positive PET-CT (P = 0.01) and maximum standardized uptake values of <5.0 (P = 0.01). CONCLUSION: FDG PET-CT has diagnostic and prognostic implications in treated patient of head and neck cancers.