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Impact and prognostic value of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scan in the evaluation of residual head and neck cancer: Single-center experience from Pakistan

BACKGROUND: Overview of clinical impact of positron emission tomography-computed tomography (PET-CT) scans in patients with head and neck carcinomas at our center. METHODS: Retrospective review of posttreatment (18)F-fluorodeoxyglucose ((18)F-FDG) PET-CT scans in patients with head and neck carcinom...

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Autores principales: Riaz, Saima, Bashir, Humayun, Iqbal, Hassan, Jamshed, Arif, Murtaza, Ahmad, Hussain, Raza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506818/
https://www.ncbi.nlm.nih.gov/pubmed/28702415
http://dx.doi.org/10.4103/2278-330X.208851
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author Riaz, Saima
Bashir, Humayun
Iqbal, Hassan
Jamshed, Arif
Murtaza, Ahmad
Hussain, Raza
author_facet Riaz, Saima
Bashir, Humayun
Iqbal, Hassan
Jamshed, Arif
Murtaza, Ahmad
Hussain, Raza
author_sort Riaz, Saima
collection PubMed
description BACKGROUND: Overview of clinical impact of positron emission tomography-computed tomography (PET-CT) scans in patients with head and neck carcinomas at our center. METHODS: Retrospective review of posttreatment (18)F-fluorodeoxyglucose ((18)F-FDG) PET-CT scans in patients with head and neck carcinomas with risk of residual disease. Clinical outcome served as the reference standard. RESULTS: This study included 93 patients (65.6% males, mean age: 48.8 years ± 17.2 standard deviation) with squamous cell carcinoma as most frequent histopathology (91.4%). PET-CT scans were performed on average 6 months posttreatment. Diagnostic accuracy, positive predictive value, and negative predictive value of PET-CT for disease were found to be 88%, 88%, and 92%, respectively. A median follow-up of 24 months was available for 91 patients. Kaplan–Meier curves showed significantly higher disease-free survival with negative PET-CT as compared to positive PET-CT (P = 0.01) and maximum standardized uptake values of <5.0 (P = 0.01). CONCLUSION: FDG PET-CT has diagnostic and prognostic implications in treated patient of head and neck cancers.
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spelling pubmed-55068182017-07-12 Impact and prognostic value of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scan in the evaluation of residual head and neck cancer: Single-center experience from Pakistan Riaz, Saima Bashir, Humayun Iqbal, Hassan Jamshed, Arif Murtaza, Ahmad Hussain, Raza South Asian J Cancer ORIGINAL ARTICLE: SAARC Selection BACKGROUND: Overview of clinical impact of positron emission tomography-computed tomography (PET-CT) scans in patients with head and neck carcinomas at our center. METHODS: Retrospective review of posttreatment (18)F-fluorodeoxyglucose ((18)F-FDG) PET-CT scans in patients with head and neck carcinomas with risk of residual disease. Clinical outcome served as the reference standard. RESULTS: This study included 93 patients (65.6% males, mean age: 48.8 years ± 17.2 standard deviation) with squamous cell carcinoma as most frequent histopathology (91.4%). PET-CT scans were performed on average 6 months posttreatment. Diagnostic accuracy, positive predictive value, and negative predictive value of PET-CT for disease were found to be 88%, 88%, and 92%, respectively. A median follow-up of 24 months was available for 91 patients. Kaplan–Meier curves showed significantly higher disease-free survival with negative PET-CT as compared to positive PET-CT (P = 0.01) and maximum standardized uptake values of <5.0 (P = 0.01). CONCLUSION: FDG PET-CT has diagnostic and prognostic implications in treated patient of head and neck cancers. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5506818/ /pubmed/28702415 http://dx.doi.org/10.4103/2278-330X.208851 Text en Copyright: © 2017 The South Asian Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle ORIGINAL ARTICLE: SAARC Selection
Riaz, Saima
Bashir, Humayun
Iqbal, Hassan
Jamshed, Arif
Murtaza, Ahmad
Hussain, Raza
Impact and prognostic value of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scan in the evaluation of residual head and neck cancer: Single-center experience from Pakistan
title Impact and prognostic value of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scan in the evaluation of residual head and neck cancer: Single-center experience from Pakistan
title_full Impact and prognostic value of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scan in the evaluation of residual head and neck cancer: Single-center experience from Pakistan
title_fullStr Impact and prognostic value of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scan in the evaluation of residual head and neck cancer: Single-center experience from Pakistan
title_full_unstemmed Impact and prognostic value of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scan in the evaluation of residual head and neck cancer: Single-center experience from Pakistan
title_short Impact and prognostic value of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scan in the evaluation of residual head and neck cancer: Single-center experience from Pakistan
title_sort impact and prognostic value of (18)f-fluorodeoxyglucose positron emission tomography-computed tomography scan in the evaluation of residual head and neck cancer: single-center experience from pakistan
topic ORIGINAL ARTICLE: SAARC Selection
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506818/
https://www.ncbi.nlm.nih.gov/pubmed/28702415
http://dx.doi.org/10.4103/2278-330X.208851
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