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The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting
Porous hydroxyapatite (HA) scaffolds with porosity-graded structures were fabricated by sequential freeze-casting. The pore structures, compressive strengths, and biocompatibilities of the fabricated porous HA scaffolds were evaluated. The porosities of the inner and outer layers of the graded HA sc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506897/ https://www.ncbi.nlm.nih.gov/pubmed/28772735 http://dx.doi.org/10.3390/ma10040367 |
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author | Lee, Hyun Jang, Tae-Sik Song, Juha Kim, Hyoun-Ee Jung, Hyun-Do |
author_facet | Lee, Hyun Jang, Tae-Sik Song, Juha Kim, Hyoun-Ee Jung, Hyun-Do |
author_sort | Lee, Hyun |
collection | PubMed |
description | Porous hydroxyapatite (HA) scaffolds with porosity-graded structures were fabricated by sequential freeze-casting. The pore structures, compressive strengths, and biocompatibilities of the fabricated porous HA scaffolds were evaluated. The porosities of the inner and outer layers of the graded HA scaffolds were controlled by adjusting the initial HA contents of the casting slurries. The interface between the dense and porous parts was compact and tightly adherent. The porosity and compressive strengths of the scaffold were controlled by the relative thicknesses of the dense/porous parts. In addition, the porous HA scaffolds showed good biocompatibility in terms of preosteoblast cell attachment and proliferation. The results suggest that porous HA scaffolds with load-bearing parts have potential as bone grafts in hard-tissue engineering. |
format | Online Article Text |
id | pubmed-5506897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55068972017-07-28 The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting Lee, Hyun Jang, Tae-Sik Song, Juha Kim, Hyoun-Ee Jung, Hyun-Do Materials (Basel) Article Porous hydroxyapatite (HA) scaffolds with porosity-graded structures were fabricated by sequential freeze-casting. The pore structures, compressive strengths, and biocompatibilities of the fabricated porous HA scaffolds were evaluated. The porosities of the inner and outer layers of the graded HA scaffolds were controlled by adjusting the initial HA contents of the casting slurries. The interface between the dense and porous parts was compact and tightly adherent. The porosity and compressive strengths of the scaffold were controlled by the relative thicknesses of the dense/porous parts. In addition, the porous HA scaffolds showed good biocompatibility in terms of preosteoblast cell attachment and proliferation. The results suggest that porous HA scaffolds with load-bearing parts have potential as bone grafts in hard-tissue engineering. MDPI 2017-03-31 /pmc/articles/PMC5506897/ /pubmed/28772735 http://dx.doi.org/10.3390/ma10040367 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Hyun Jang, Tae-Sik Song, Juha Kim, Hyoun-Ee Jung, Hyun-Do The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting |
title | The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting |
title_full | The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting |
title_fullStr | The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting |
title_full_unstemmed | The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting |
title_short | The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting |
title_sort | production of porous hydroxyapatite scaffolds with graded porosity by sequential freeze-casting |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506897/ https://www.ncbi.nlm.nih.gov/pubmed/28772735 http://dx.doi.org/10.3390/ma10040367 |
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