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Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3

Cardiovascular disease is one of the main burdens of healthcare systems worldwide. Nevertheless, assessing cardiovascular risk in both apparently healthy individuals and low/high-risk patients remains a difficult issue. Already established biomarkers (e.g. brain natriuretic peptide, troponin) have s...

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Autores principales: Hogas, Simona, Bilha, Stefana C., Branisteanu, Dumitru, Hogas, Mihai, Gaipov, Abduzhappar, Kanbay, Mehmet, Covic, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507105/
https://www.ncbi.nlm.nih.gov/pubmed/28721158
http://dx.doi.org/10.5114/aoms.2016.58664
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author Hogas, Simona
Bilha, Stefana C.
Branisteanu, Dumitru
Hogas, Mihai
Gaipov, Abduzhappar
Kanbay, Mehmet
Covic, Adrian
author_facet Hogas, Simona
Bilha, Stefana C.
Branisteanu, Dumitru
Hogas, Mihai
Gaipov, Abduzhappar
Kanbay, Mehmet
Covic, Adrian
author_sort Hogas, Simona
collection PubMed
description Cardiovascular disease is one of the main burdens of healthcare systems worldwide. Nevertheless, assessing cardiovascular risk in both apparently healthy individuals and low/high-risk patients remains a difficult issue. Already established biomarkers (e.g. brain natriuretic peptide, troponin) have significantly improved the assessment of major cardiovascular events and diseases but cannot be applied to all patients and in some cases do not provide sufficiently accurate information. In this context, new potential biomarkers that reflect various underlying pathophysiological cardiac and vascular modifications are needed. Also, a multiple biomarker evaluation that shows changes in the cardiovascular state is of interest. This review describes the role of selected markers of vascular inflammation, atherosclerosis, atherothrombosis, endothelial dysfunction and cardiovascular fibrosis in the pathogenesis and prognosis of cardiovascular disease: the potential use of cardiotrophin-1, leptin, adiponectin, resistin and galectin-3 as biomarkers for various cardiovascular conditions is discussed.
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spelling pubmed-55071052017-07-18 Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3 Hogas, Simona Bilha, Stefana C. Branisteanu, Dumitru Hogas, Mihai Gaipov, Abduzhappar Kanbay, Mehmet Covic, Adrian Arch Med Sci State of the Art Paper Cardiovascular disease is one of the main burdens of healthcare systems worldwide. Nevertheless, assessing cardiovascular risk in both apparently healthy individuals and low/high-risk patients remains a difficult issue. Already established biomarkers (e.g. brain natriuretic peptide, troponin) have significantly improved the assessment of major cardiovascular events and diseases but cannot be applied to all patients and in some cases do not provide sufficiently accurate information. In this context, new potential biomarkers that reflect various underlying pathophysiological cardiac and vascular modifications are needed. Also, a multiple biomarker evaluation that shows changes in the cardiovascular state is of interest. This review describes the role of selected markers of vascular inflammation, atherosclerosis, atherothrombosis, endothelial dysfunction and cardiovascular fibrosis in the pathogenesis and prognosis of cardiovascular disease: the potential use of cardiotrophin-1, leptin, adiponectin, resistin and galectin-3 as biomarkers for various cardiovascular conditions is discussed. Termedia Publishing House 2016-03-22 2017-06 /pmc/articles/PMC5507105/ /pubmed/28721158 http://dx.doi.org/10.5114/aoms.2016.58664 Text en Copyright: © 2016 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle State of the Art Paper
Hogas, Simona
Bilha, Stefana C.
Branisteanu, Dumitru
Hogas, Mihai
Gaipov, Abduzhappar
Kanbay, Mehmet
Covic, Adrian
Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3
title Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3
title_full Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3
title_fullStr Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3
title_full_unstemmed Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3
title_short Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3
title_sort potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3
topic State of the Art Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507105/
https://www.ncbi.nlm.nih.gov/pubmed/28721158
http://dx.doi.org/10.5114/aoms.2016.58664
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