Tissue plasminogen activator mediates deleterious complement cascade activation in stroke

The use of intravenous tissue plasminogen activator (tPA) in the treatment of ischemic stroke is limited by its propensity to exacerbate brain edema and hemorrhage. The mechanisms underlying these deleterious effects of tPA remain incompletely understood. The purpose of this study was to delineate a...

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Detalles Bibliográficos
Autores principales: Zhao, Xue-Jun, Larkin, Timothy M., Lauver, Molly A., Ahmad, Saif, Ducruet, Andrew F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507253/
https://www.ncbi.nlm.nih.gov/pubmed/28700732
http://dx.doi.org/10.1371/journal.pone.0180822

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