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Protocols to Study Aging in Drosophila

The fruit fly Drosophila melanogaster offers a host of advantages for studying the biology of aging: a well-understood biology, a wide range of genetic reagents, well-defined dietary requirements, and a relatively short life span, with a median of ~80 days and maximum ~100 days. Several phenotypes c...

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Detalles Bibliográficos
Autores principales: Piper, Matthew D. W., Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer New York 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507281/
https://www.ncbi.nlm.nih.gov/pubmed/27730590
http://dx.doi.org/10.1007/978-1-4939-6371-3_18
Descripción
Sumario:The fruit fly Drosophila melanogaster offers a host of advantages for studying the biology of aging: a well-understood biology, a wide range of genetic reagents, well-defined dietary requirements, and a relatively short life span, with a median of ~80 days and maximum ~100 days. Several phenotypes can be used to assess the aging process, but the simplest and most widely used metric is length of life. Here we describe a standard life span assay for Drosophila housed on a simple sugar/yeast diet.