Cargando…
Spatial location of neutralizing and non-neutralizing B cell epitopes on domain 1 of ricin toxin’s binding subunit
Ricin toxin’s binding subunit (RTB) is a galactose-/N-acetylgalactosamine (Gal/GalNac)-specific lectin that mediates uptake and intracellular trafficking of ricin within mammalian cells. Structurally, RTB consists of two globular domains, each divided into three homologous sub-domains (α, β, γ). In...
Autores principales: | Rong, Yinghui, Van Slyke, Greta, Vance, David J., Westfall, Jennifer, Ehrbar, Dylan, Mantis, Nicholas J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507285/ https://www.ncbi.nlm.nih.gov/pubmed/28700745 http://dx.doi.org/10.1371/journal.pone.0180999 |
Ejemplares similares
-
A Supercluster of Neutralizing Epitopes at the Interface of Ricin’s Enzymatic (RTA) and Binding (RTB) Subunits
por: Poon, Amanda Y., et al.
Publicado: (2017) -
Sub-Domains of Ricin’s B Subunit as Targets of Toxin Neutralizing and Non-Neutralizing Monoclonal Antibodies
por: Yermakova, Anastasiya, et al.
Publicado: (2012) -
Sites of vulnerability on ricin B chain revealed through epitope mapping of toxin-neutralizing monoclonal antibodies
por: Vance, David J., et al.
Publicado: (2020) -
Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin’s Enzymatic Subunit Interfere with Intracellular Toxin Transport
por: Yermakova, Anastasiya, et al.
Publicado: (2016) -
Durable Immunity to Ricin Toxin Elicited by a Thermostable, Lyophilized Subunit Vaccine
por: Novak, Hayley, et al.
Publicado: (2021)