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Bicytopenia and leukoerythroblastosis: a rare initial presentation of signet ring cell gastric adenocarcinoma
Gastric adenocarcinoma is a common neoplasia and is responsible for up to 30% of the overall deaths due to cancer. Advanced disease is mostly characterized by peritoneum, liver, and lung involvement. The spread of the disease to the bone is rare, and bone marrow dissemination is even rarer. In this...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
São Paulo, SP: Universidade de São Paulo, Hospital Universitário
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507570/ https://www.ncbi.nlm.nih.gov/pubmed/28740840 http://dx.doi.org/10.4322/acr.2017.014 |
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author | Takayasu, Vilma Goto, Edna Harumi Casagrande, Mayra Zanon Miranda, Paulo Guilherme de Arruda Diniz, Gabriela Bezerra de Freitas Monteiro, Micaela Frasson Felipe-Silva, Aloisio |
author_facet | Takayasu, Vilma Goto, Edna Harumi Casagrande, Mayra Zanon Miranda, Paulo Guilherme de Arruda Diniz, Gabriela Bezerra de Freitas Monteiro, Micaela Frasson Felipe-Silva, Aloisio |
author_sort | Takayasu, Vilma |
collection | PubMed |
description | Gastric adenocarcinoma is a common neoplasia and is responsible for up to 30% of the overall deaths due to cancer. Advanced disease is mostly characterized by peritoneum, liver, and lung involvement. The spread of the disease to the bone is rare, and bone marrow dissemination is even rarer. In this setting, leukoerythroblastosis may be the initial manifestation of the disease. The authors report the case of a 64-year-old Caucasian man who sought medical care complaining of back pain, weakness, and weight loss. The physical examination revealed pallor, and the laboratory work-up depicted severe anemia and thrombocytopenia; the peripheral blood smear was consistent with leukoerythroblastosis. The ongoing investigation through a bone marrow biopsy showed massive involvement of the bone marrow by a signet ring cell adenocarcinoma. During hospitalization, the patient presented melena, and an upper digestive endoscopy depicted an ulcerated and infiltrative lesion in the cardia, upon which the histological examination revealed a signet ring cell adenocarcinoma. This case highlights the bone marrow invasion represented by bicytopenia and leukoerythroblastosis as the initial manifestation of this histological type of gastric cancer. Although treatment attempts were made with chemotherapy and radiotherapy, the patient died early on, showing the aggressive behavior of this form of tumoral presentation. |
format | Online Article Text |
id | pubmed-5507570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | São Paulo, SP: Universidade de São Paulo, Hospital Universitário |
record_format | MEDLINE/PubMed |
spelling | pubmed-55075702017-07-24 Bicytopenia and leukoerythroblastosis: a rare initial presentation of signet ring cell gastric adenocarcinoma Takayasu, Vilma Goto, Edna Harumi Casagrande, Mayra Zanon Miranda, Paulo Guilherme de Arruda Diniz, Gabriela Bezerra de Freitas Monteiro, Micaela Frasson Felipe-Silva, Aloisio Autops Case Rep Article / Clinical Case Report Gastric adenocarcinoma is a common neoplasia and is responsible for up to 30% of the overall deaths due to cancer. Advanced disease is mostly characterized by peritoneum, liver, and lung involvement. The spread of the disease to the bone is rare, and bone marrow dissemination is even rarer. In this setting, leukoerythroblastosis may be the initial manifestation of the disease. The authors report the case of a 64-year-old Caucasian man who sought medical care complaining of back pain, weakness, and weight loss. The physical examination revealed pallor, and the laboratory work-up depicted severe anemia and thrombocytopenia; the peripheral blood smear was consistent with leukoerythroblastosis. The ongoing investigation through a bone marrow biopsy showed massive involvement of the bone marrow by a signet ring cell adenocarcinoma. During hospitalization, the patient presented melena, and an upper digestive endoscopy depicted an ulcerated and infiltrative lesion in the cardia, upon which the histological examination revealed a signet ring cell adenocarcinoma. This case highlights the bone marrow invasion represented by bicytopenia and leukoerythroblastosis as the initial manifestation of this histological type of gastric cancer. Although treatment attempts were made with chemotherapy and radiotherapy, the patient died early on, showing the aggressive behavior of this form of tumoral presentation. São Paulo, SP: Universidade de São Paulo, Hospital Universitário 2017-06-30 /pmc/articles/PMC5507570/ /pubmed/28740840 http://dx.doi.org/10.4322/acr.2017.014 Text en Autopsy and Case Reports. ISSN 2236-1960. Copyright © 2017. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the article is properly cited. |
spellingShingle | Article / Clinical Case Report Takayasu, Vilma Goto, Edna Harumi Casagrande, Mayra Zanon Miranda, Paulo Guilherme de Arruda Diniz, Gabriela Bezerra de Freitas Monteiro, Micaela Frasson Felipe-Silva, Aloisio Bicytopenia and leukoerythroblastosis: a rare initial presentation of signet ring cell gastric adenocarcinoma |
title | Bicytopenia and leukoerythroblastosis: a rare initial presentation of signet ring cell gastric adenocarcinoma |
title_full | Bicytopenia and leukoerythroblastosis: a rare initial presentation of signet ring cell gastric adenocarcinoma |
title_fullStr | Bicytopenia and leukoerythroblastosis: a rare initial presentation of signet ring cell gastric adenocarcinoma |
title_full_unstemmed | Bicytopenia and leukoerythroblastosis: a rare initial presentation of signet ring cell gastric adenocarcinoma |
title_short | Bicytopenia and leukoerythroblastosis: a rare initial presentation of signet ring cell gastric adenocarcinoma |
title_sort | bicytopenia and leukoerythroblastosis: a rare initial presentation of signet ring cell gastric adenocarcinoma |
topic | Article / Clinical Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507570/ https://www.ncbi.nlm.nih.gov/pubmed/28740840 http://dx.doi.org/10.4322/acr.2017.014 |
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